Evidence map›Paper›PMID 29200711›Full record

ArticlePharmacognosy magazine

Biological Activities and Cytotoxicity of

Fernanda Torlania Alves Gomes, Ana Paula de Araújo Boleti, Lidiam M Leandro, Diego Squinello, Ellen S P Aranha, Marne C Vasconcelos, Paul Cos, Valdir F Veiga-Junior, Emerson Silva Lima

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacognosy magazine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Advancing the Chemical Characterization ofPlants (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Fernanda Torlania Alves GomesBiological Activity Laboratory, Faculty of Pharmaceutical Sciences, Federal University of Amazonas, Manaus, Amazonas, Brazil.
Ana Paula de Araújo BoletiBiological Activity Laboratory, Faculty of Pharmaceutical Sciences, Federal University of Amazonas, Manaus, Amazonas, Brazil.
Lidiam M LeandroChemistry Department, Exact Sciences Institute, Federal University of Amazonas, Manaus, Amazonas, Brazil.
Diego SquinelloChemistry Department, Exact Sciences Institute, Federal University of Amazonas, Manaus, Amazonas, Brazil.
Ellen S P AranhaBiological Activity Laboratory, Faculty of Pharmaceutical Sciences, Federal University of Amazonas, Manaus, Amazonas, Brazil.
Marne C VasconcelosBiological Activity Laboratory, Faculty of Pharmaceutical Sciences, Federal University of Amazonas, Manaus, Amazonas, Brazil.
Paul CosLaboratory of Microbiology, Parasitology and Hygiene, University of Antwerp, B2610 Antwerp, Belgium.
Valdir F Veiga-JuniorChemistry Department, Exact Sciences Institute, Federal University of Amazonas, Manaus, Amazonas, Brazil.
Emerson Silva LimaBiological Activity Laboratory, Faculty of Pharmaceutical Sciences, Federal University of Amazonas, Manaus, Amazonas, Brazil.
Universidade Federal do Amazonas · BRUniversity of Antwerp · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe oil-resin of

objectiveThis study aimed to investigate the effects of the acid fraction of MATERIALS AND

methodsAcid fraction of

resultsThe predominant acidic diterpenes in the AFEOR were copalic and hardwickiic acids. AFEOR caused morphology alteration and decrease of proliferation at concentrations higher than 5 μg/mL. It also caused significant collagen proliferation in fibroblasts. It showed cytotoxicity against tumoral and nontumoral cell lines, with IC

conclusionFor the first time, biological activities from oil-resin SUMMARY: Analysis of crude oil-resin and fractionation of diterpenic fraction was performance using selective ion-exchange column chromatographyCytotoxicity analysis and morphology were performed with different cell linesCollagen production in human fibroblasts, inhibition of metalloproteinases were demonstrated by zymography and Western blotting.

Indexed as

collagenaseEperuametalloproteinasestumoral cell

Identifiers

PMID29200711
PMCPMC5701389
OpenAlexW2768241769

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.