ArticleJournal of occupational and environmental medicine2017
Incidence of Occupational Asthma and Exposure to Toluene Diisocyanate in the United States Toluene Diisocyanate Production Industry.
Article in Journal of occupational and environmental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Is Isocyanate Exposure and Occupational Asthma Still a Major Occupational Health Concern? Systematic Literature Review.International journal of environmental research and public health · 2021Pooled it
- Occupational Exposure to Volatile Organic Compounds in Polyurethane Foam Production-Concentration, Variability and Health Risk Assessment.Molecules (Basel, Switzerland) · 2026Article
- Pesticides impacts on human health and the environment with their mechanisms of action and possible countermeasures.Heliyon · 2024Review
- Reduced Isocyanate Release Using a Waterproof, Resin-Based Cast Alternative Relative to Fiberglass Casts.Toxics · 2023Article
- Article
- Author's Response to Letters to the Editor regarding "Risk Assessment for Toluene Diisocyanate and Respiratory Disease Human Studies".Safety and health at work · 2022Article
- Letter to the Editor Regarding "Risk Assessment for Toluene Diisocyanate and Respiratory Disease Human Studies".Safety and health at work · 2022Article
- Letter to the Editor Concerning "Risk Assessment for Toluene Diisocyanate and Respiratory Disease Human Studies".Safety and health at work · 2022Article
- Risk Assessment for Toluene Diisocyanate and Respiratory Disease Human Studies.Safety and health at work · 2021Article
- Scoping Review-The Association between Asthma and Environmental Chemicals.International journal of environmental research and public health · 2021Article
- The AKT inhibitor MK2206 suppresses airway inflammation and the pro‑remodeling pathway in a TDI‑induced asthma mouse model.Molecular medicine reports · 2020Article
- Practical learnings from an epidemiology study on TDI-related occupational asthma: Part II-Exposure without respiratory protection to TWA-8 values indicative of peak events is a good indicator of risk.Toxicology and industrial health · 2020Article
- Practical learnings from an epidemiology study on TDI-related occupational asthma: Part I-Cumulative exposure is not a good indicator of risk.Toxicology and industrial health · 2020Article
- Peak Inhalation Exposure Metrics Used in Occupational Epidemiologic and Exposure Studies.Frontiers in public health · 2020Review
- Salicylic acid amplifies Carbachol-induced bronchoconstriction in human precision-cut lung slices.Respiratory research · 2019Article
- Serum Periostin Levels: A Potential Serologic Marker for Toluene Diisocyanate-Induced Occupational Asthma.Yonsei medical journal · 2018Article
- Longitudinal and Cross-sectional Analyses of Lung Function in Toluene Diisocyanate Production Workers.Journal of occupational and environmental medicine · 2017Article
- Medical Monitoring for Occupational Asthma Among Toluene Diisocyanate Production Workers in the United States.Journal of occupational and environmental medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
objectiveThis study examines asthma risk in facilities producing toluene diisocyanate (TDI).
methodsA total of 197 workers were monitored from 2007 to 2012. TDI air concentrations were used to estimate exposures.
resultsThe incidence of cases consistent with TDI-induced asthma was 0.009 per person-years (seven cases) or consistent with TDI-induced asthma or asthma indeterminate regarding work-relatedness was 0.012 (nine cases). Increased risk of cases consistent with TDI asthma was observed for cumulative (odds ratio [OR] = 2.08, 95% confidence interval [CI] 1.07 to 4.05) per logarithm parts per billion-years and peak TDI exposures (OR = 1.18, 95% CI 1.06 to 1.32) (logarithm parts per billion). There was a weak association with cumulative and peak exposures for decline of short-term forced expiratory volume in one second (FEV1). Asthma symptoms were associated with workers noticing an odor of TDI (OR 6.02; 95% CI 1.36 to 26.68).
conclusionsThere is evidence that cumulative and peak exposures are associated with TDI-induced asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.