Evidence map›Paper›PMID 29199976›Full record

ArticleActa crystallographica. Section D, Structural biology2017

Hydrogen bonds are a primary driving force for de novo protein folding.

Schuyler Lee, Chao Wang, Haolin Liu, Jian Xiong, Renee Jiji, Xia Hong, Xiaoxue Yan, Zhangguo Chen, Michal Hammel, Yang Wang and 4 more

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta crystallographica. Section D, Structural biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Hydrogen bonds are a primary driving force for de novo protein folding. Corrigendum.Acta crystallographica. Section D, Structural biology · 2018
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Schuyler LeeDepartment of Biomedical Research, National Jewish Health, Denver, CO 80206, USA.
Chao WangDepartment of Biomedical Research, National Jewish Health, Denver, CO 80206, USA.
Haolin LiuDepartment of Biomedical Research, National Jewish Health, Denver, CO 80206, USA.
Jian XiongDepartment of Chemistry, University of Missouri, Columbus, Mississippi, USA.
Renee JijiDepartment of Chemistry, University of Missouri, Columbus, Mississippi, USA.
Xia HongDepartment of Biomedical Research, National Jewish Health, Denver, CO 80206, USA.
Xiaoxue YanDepartment of Biomedical Research, National Jewish Health, Denver, CO 80206, USA.ORCID 0000-0002-8266-0613
Zhangguo ChenDepartment of Immunology and Microbiology, School of Medicine, University of Colorado Denver, Aurora, CO 80206, USA.
Michal HammelPhysical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Yang WangDepartment of Biomedical Research, National Jewish Health, Denver, CO 80206, USA.ORCID 0000-0002-6510-6653
Shaodong DaiDepartment of Biomedical Research, National Jewish Health, Denver, CO 80206, USA.ORCID 0000-0003-4760-2773
Jing WangDepartment of Immunology and Microbiology, School of Medicine, University of Colorado Denver, Aurora, CO 80206, USA.
Chengyu JiangDepartment of Biochemistry and Molecular Biology, Peking Union Medical College, Beijing 100005, People's Republic of China.
Gongyi ZhangDepartment of Biomedical Research, National Jewish Health, Denver, CO 80206, USA.
National Jewish Health · USUniversity of Colorado Denver · USUniversity of Mississippi · USChinese Academy of Medical Sciences & Peking Union Medical College · CNLawrence Berkeley National Laboratory · US

Funding

Transcription-Coupled & Replication-Associated Excision RepairP01CA092584 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI John A. Tainer · 2001 to 2026
$89.6M
THE REGULATION OF V ALPHA 7 EXPRESSING T CELLSP01AI022295 · NIAID · NATIONAL JEWISH HEALTH · PI REFAELI, YOSEF · 1985 to 2011
$11.7M
TRAINING PROGRAM IN IMMUNOLOGYT32AI007405 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Laurel L Lenz, Raul Martin Torres · 1991 to 2026
$10.5M
Molecular Mechanisms of Immune ToleranceT32AI074491 · NIAID · NATIONAL JEWISH HEALTH · PI CAMBIER, JOHN C, PELANDA, ROBERTA · 2009 to 2023
$4.1M
Molecular Basis of T Cell Recognition of Metal IonsR01ES025797 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI DAI, SHAODONG · 2015 to 2019
$1.8M
Regulation of V(D)J Recombination by Arginine MethylationR21AI115696 · NIAID · NATIONAL JEWISH HEALTH · PI HAGMAN, JAMES R. · 2015 to 2016
$436k
Lipid Ligands of SPLUNC1 ProteinsR21AI109219 · NIAID · NATIONAL JEWISH HEALTH · PI ZHANG, GONGYI · 2014 to 2015
$436k
Heavy Metal Induced AutoimmunityR21ES025885 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI DAI, SHAODONG · 2017 to 2018
$432k
NCI NIH HHS CA92584NCI NIH HHS P01 CA092584NIAID NIH HHS P01 AI022295NIAID NIH HHS R21 AI109219NIAID NIH HHS R21 AI115696NIAID NIH HHS T32 AI007405NIAID NIH HHS T32 AI074491NIEHS NIH HHS R01 ES025797NIEHS NIH HHS R21 ES025885NIH HHS AI109219NIH HHS AI115696NIH HHS AI22295NIH HHS T32 5T32AI074491-07NIH HHS T32 AI 7405-27
6 · The paper itself

Abstract

The protein-folding mechanism remains a major puzzle in life science. Purified soluble activation-induced cytidine deaminase (AID) is one of the most difficult proteins to obtain. Starting from inclusion bodies containing a C-terminally truncated version of AID (residues 1-153; AID

Indexed as

Hydrogen BondingProtein FoldingAICDA (Activation-Induced Cytidine Deaminase)Cytidine DeaminaseHumansProlineProtein ConformationProtein DenaturationAICDA (Activation-Induced Cytidine Deaminase)Cytidine DeaminaseProlinecis/trans-prolinehydrogen bondsprotein folding

Identifiers

PMID29199976
PMCPMC5713874
OpenAlexW2770542770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.