Evidence map›Paper›PMID 29199946›Full record

ArticleeLife2017

Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells.

Pedro Lee, Rupali Gund, Abhik Dutta, Neha Pincha, Isha Rana, Subhasri Ghosh, Deborah Witherden, Eve Kandyba, Amanda MacLeod, Krzysztof Kobielak and 2 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 77 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Hallmarks of regeneration.Cell stem cell · 2024
    Review
  7. Article
  8. Cellular and molecular mechanisms of skin wound healing.Nature reviews. Molecular cell biology · 2024
    Review
  9. Article
  10. iScience · 2024
    Article
  11. Review
  12. Article
  13. Approaches to Study Wound-Induced Hair Neogenesis (WIHN).Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  14. Article
  15. Blank Spots in the Map of Human Skin: The Challenge for Xenotransplantation.International journal of molecular sciences · 2023
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Pedro LeeSection of Cell and Developmental Biology, University of California, San Diego, La Jolla, United States.
Rupali GundIFOM-inStem Joint Research Laboratory, Centre for Inflammation and Tissue Homeostasis, Institute for Stem Cell Biology and Regenerative Medicine, Bangalore, India.
Abhik DuttaIFOM-inStem Joint Research Laboratory, Centre for Inflammation and Tissue Homeostasis, Institute for Stem Cell Biology and Regenerative Medicine, Bangalore, India.
Neha PinchaIFOM-inStem Joint Research Laboratory, Centre for Inflammation and Tissue Homeostasis, Institute for Stem Cell Biology and Regenerative Medicine, Bangalore, India.
Isha RanaIFOM-inStem Joint Research Laboratory, Centre for Inflammation and Tissue Homeostasis, Institute for Stem Cell Biology and Regenerative Medicine, Bangalore, India.
Subhasri GhoshIFOM-inStem Joint Research Laboratory, Centre for Inflammation and Tissue Homeostasis, Institute for Stem Cell Biology and Regenerative Medicine, Bangalore, India.
Deborah WitherdenDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, United States.
Eve KandybaEli and Edythe Broad Center for Regenerative Medicine & Stem Cell Research, Department of Pathology, University of Southern California, Los Angeles, United States.
Amanda MacLeodDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, United States.
Krzysztof KobielakEli and Edythe Broad Center for Regenerative Medicine & Stem Cell Research, Department of Pathology, University of Southern California, Los Angeles, United States.
Wendy L HavranDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, United States.
Colin JamoraIFOM-inStem Joint Research Laboratory, Centre for Inflammation and Tissue Homeostasis, Institute for Stem Cell Biology and Regenerative Medicine, Bangalore, India.ORCID 0000-0003-2127-2972
Institute for Stem Cell Biology and Regenerative Medicine · INScripps Research Institute · USUniversity of Southern California · USManipal Academy of Higher Education · INUniversity of California San Diego · US

Funding

PATHOGENESIS AND IMMUNOLOGY OF DISEASET32AI007244 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI NEMAZEE, DAVID · 1985 to 2022
$8.8M
JAML: A New Costimulatory Molecule for Gamma Delta T CellsR01AI064811 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI HAVRAN, WENDY L. · 2006 to 2016
$4.8M
EPITHELIAL T CELL SECRETION OF TISSUE SPECIFIC CYTOKINESR01AI036964 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI HAVRAN, WENDY L. · 1996 to 2012
$3.7M
Activator Inhibitor interactions in the cyclic regeneration of hair follicle stemR01AR061552 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KOBIELAK, KRZYSZTOF · 2012 to 2016
$1.8M
The role of the transcription factor Snail in hair morphogenesisR01AR053185 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JAMORA, COLIN · 2006 to 2010
$1.1M
Novel Role for Caspase-8 in Epidermal Homeostasis and Wound HealingF31AR056593 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LEE, PEDRO · 2009 to 2011
$70k
DBT-Wellcome Trust India Alliance IA/E/13/1/501239NIAID NIH HHS R01 AI036964NIAID NIH HHS R01 AI064811NIAID NIH HHS T32 AI007244NIAMS NIH HHS F31 AR056593NIAMS NIH HHS R01 AR053185NIAMS NIH HHS R01 AR061552Wellcome Trust
6 · The paper itself

Abstract

The cutaneous wound-healing program is a product of a complex interplay among diverse cell types within the skin. One fundamental process that is mediated by these reciprocal interactions is the mobilization of local stem cell pools to promote tissue regeneration and repair. Using the ablation of epidermal caspase-8 as a model of wound healing in

Indexed as

Cell ProliferationWound HealingAnimalsHair FollicleInterleukin-1alphaInterleukin-7Intraepithelial LymphocytesLymphocyte ActivationMiceModels, AnimalStem CellsInterleukin-1alphaInterleukin-7caspase-8cell biologydevelopmental biologyinterleukinmouseskinstem cellsT-cellswound healing

Identifiers

PMID29199946
PMCPMC5714500
OpenAlexW2772036058

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.