ArticleBiodemography and social biology2017
Inflammation and Cognition in Older Adults: Evidence from Taiwan.
Article in Biodemography and social biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cytokines and immune biomarkers in neurodegeneration and cognitive function: A systematic review among individuals of African ancestry.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Biomarkers of endothelial dysfunction and cognition: A two-step IPD meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Resolution of elevated interleukin-6 after surgery is associated with return of normal cognitive function.British journal of anaesthesia · 2023Article
- Network analysis of the associations between personality traits, cognitive functioning, and inflammatory markers in elderly individuals without dementia.Frontiers in aging neuroscience · 2023Article
- Cognitive changes mediated by adenosine receptor blockade in a resveratrol-treated atherosclerosis-prone lupus mouse model.Journal of traditional and complementary medicine · 2022Article
- Adulthood systemic inflammation accelerates the trajectory of age-related cognitive decline.Aging · 2021Article
- Systemic Inflammation Mediates Age-Related Cognitive Deficits.Frontiers in aging neuroscience · 2018Article
- Apolipoprotein E, cognitive function, and cognitive decline among older Taiwanese adults.PloS one · 2018Article
- Impact of Age on Plasma Inflammatory Biomarkers in the 6 Months Following Mild Traumatic Brain Injury.The Journal of head trauma rehabilitationArticle
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Abstract
Inflammation has been linked to clinical cognitive impairment, including Alzheimer's disease. Less is known, however, about the relationship between inflammation and normal, age-associated cognitive decline. An understanding of the determinants of all types of cognitive decline is important for improving quality of life in an aging world. This study investigated whether biomarkers of inflammation were associated with cognitive function and decline in older Taiwanese adults. Data were from the Taiwan Longitudinal Study of Aging and the Social Environment and Biomarkers of Aging Study. Inflammation was measured in 2000 and 2006 as C-reactive protein, interleukin-6, soluble e-selectin, soluble intercellular adhesion molecule-1, and white blood cell count. Cognition was assessed by 10 cognitive and memory tasks, measured in 2006, 2007, and 2011. Growth curve models were used to examine the relationship between inflammation and cognitive score over this time period. Higher levels of inflammation were associated with lower baseline cognitive scores, but not with longitudinal change in cognitive score. This study did not support a causal link between inflammation and cognitive decline among this older cohort. The observed cross-sectional relationship could reflect a causal relationship that arises earlier in life, or confounding; additional research across the life course is warranted.
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