Evidence map›Paper›PMID 29199818›Full record

ReviewACS chemical neuroscience2018

Precision Medicine in Pediatric Neurooncology: A Review.

Aaron Y Mochizuki, Isaura M Frost, Melina B Mastrodimos, Ashley S Plant, Anthony C Wang, Theodore B Moore, Robert M Prins, Paul S Weiss, Steven J Jonas

Open access · greenAbstract readReview
In one paragraph

Review in ACS chemical neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Essential Management of Pediatric Brain Tumors.Children (Basel, Switzerland) · 2022
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Immunoliposome for Ewing Sarcoma.Cancer genomics & proteomics
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Aaron Y MochizukiDepartment of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles , Los Angeles, California 90095, United States.ORCID 0000-0003-1073-916X
Isaura M FrostDepartment of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles , Los Angeles, California 90095, United States.ORCID 0000-0003-2851-1008
Melina B MastrodimosDepartment of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles , Los Angeles, California 90095, United States.ORCID 0000-0002-2529-9577
Ashley S PlantDivision of Pediatric Oncology, Children's Hospital of Orange County , Orange, California 92868, United States.
Anthony C WangDepartment of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles , Los Angeles, California 90095, United States.
Theodore B MooreDepartment of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles , Los Angeles, California 90095, United States.
Robert M PrinsDepartment of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles , Los Angeles, California 90095, United States.
Paul S WeissCalifornia NanoSystems Institute, University of California, Los Angeles , Los Angeles, California 90095, United States.ORCID 0000-0001-5527-6248
Steven J JonasCalifornia NanoSystems Institute, University of California, Los Angeles , Los Angeles, California 90095, United States.ORCID 0000-0002-8111-0249
University of California, Los Angeles · USCalifornia NanoSystems Institute · USChildren's Hospital of Orange County · US

Funding

UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yvonne Yu-Hsuan Chen · 2017 to 2026
$25.2M
NCI NIH HHS P50 CA211015NIGMS NIH HHS T32 GM008042
6 · The paper itself

Abstract

Central nervous system tumors are the leading cause of cancer related death in children. Despite much progress in the field of pediatric neurooncology, modern combination treatment regimens often result in significant late effects, such as neurocognitive deficits, endocrine dysfunction, secondary malignancies, and a host of other chronic health problems. Precision medicine strategies applied to pediatric neurooncology target specific characteristics of individual patients' tumors to achieve maximal killing of neoplastic cells while minimizing unwanted adverse effects. Here, we review emerging trends and the current literature that have guided the development of new molecularly based classification schemas, promising diagnostic techniques, targeted therapies, and delivery platforms for the treatment of pediatric central nervous system tumors.

Indexed as

Precision MedicineAnimalsCentral Nervous System NeoplasmsChildHumansneurooncologypediatricsPrecision medicinereview

Identifiers

PMID29199818
PMCPMC6656379
OpenAlexW2775389840

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.