ArticleImmunologic research2018
Autoimmune/inflammatory syndrome induced by adjuvants-ASIA-related to biomaterials: analysis of 45 cases and comprehensive review of the literature.
Article in Immunologic research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Granulomatous Sarcoidosis Mimics.Frontiers in medicine · 2021Pooled it
- Adjuvant-induced autoimmune syndrome (ASIA syndrome) and the role of sonography in its diagnosis: a case-based review.Rheumatology international · 2025Review
- Granulomatous Reactions Following the Injection of Multiple Aesthetic Microimplants: A Complication Associated with Excessive Filler Exposure in a Predisposed Patient.Reports (MDPI) · 2025Article
- Somatostatin Receptor Scintigraphy in Autoimmune Syndrome Induced by Silicone Breast Implants: Pre- and Postexplantation Findings.Journal of clinical medicine · 2025Article
- Hyaluronic acid delayed filler complications: a racial group analysis and call to action.Archives of dermatological research · 2025Review
- Systemic Lupus Erythematosus (SLE) Induced by ASIA Syndrome After the Aesthetic Medicine Procedures-A Case Report.Journal of clinical medicine · 2024Article
- ASIA Syndrome: State-of-the-Art and Future Perspectives.Vaccines · 2024Review
- Late-Onset Reactions after Hyaluronic Acid Dermal Fillers: A Consensus Recommendation on Etiology, Prevention and Management.Dermatology and therapy · 2024Review
- Photobiomodulation Therapy in the Management of Late Complications After Facial Filling.Cureus · 2024Article
- Biofilm-derived oxylipin 10-HOME mediated immune response in women with breast implants.The Journal of clinical investigation · 2024Article
- Biofilm-derived oxylipin 10-HOME-mediated immune response in women with breast implants.The Journal of clinical investigation · 2023Article
- Panniculitis as a manifestation of metal-associated autoimmune/inflammatory syndrome induced by adjuvants: a case-based review.Rheumatology international · 2023Review
- Delayed inflammatory reaction to hyaluronic acid lip filler after the Pfizer-BioNTech COVID-19 vaccine: A case report.Heliyon · 2023Article
- Clinical Use of Non-Suture Silk-Containing Products: A Systematic Review.Biomimetics (Basel, Switzerland) · 2023Review
- Hyaluronic Acid Fillers and ASIA Syndrome: Case Studies.Clinical, cosmetic and investigational dermatology · 2023Article
- Antisynthetase Syndrome Post Shingrix and Pneumovax Vaccinations, Possible Correlation.Cureus · 2022Article
- Dermal Fillers and COVID-19: Angioedema With Urticaria in a Patient Post COVID-19 Infection.Cureus · 2022Article
- Painful subacute thyroiditis occurring after the administration of influenza vaccine and hyaluronic acid dermal filler: A case report.Medicine · 2022Article
- Article
- Classification for Staging and Managing Patients with Biopolymer-induced Human Adjuvant Disease.Plastic and reconstructive surgery. Global open · 2022Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systemic autoimmune or granulomatous disorders related to biomaterials of human use have rarely been described. The aim of this study was to report cases of autoimmune/inflammatory syndrome induced by adjuvants (ASIA) related to biomaterial injections and prostheses, mainly silicone, hyaluronic acid, acrylamides and methacrylate compounds in a Spanish patient cohort. This study is a retrospective analysis of clinical, laboratory, histopathological and follow-up data of 45 cases of patients suffering from late-onset, non-infectious inflammatory/autoimmune disorders related to bioimplants. Late onset was defined as 3 months or more post injection. Data were obtained through a further non-systematic but comprehensive review of the literature. Forty-five cases of late-onset adverse reactions related to biomaterial injections or prostheses were reviewed. All cases had systemic complaints that could be categorised as ASIA. In all but four patients, inflammatory features at the implantation site preceded distant or systemic manifestations. Abnormal blood tests were common. Localised inflammatory nodules and panniculitis in 40/45 (88.88%) evolved into a variety of disorders, viz., primary biliary cirrhosis, Sjögren's syndrome, sarcoidosis, human adjuvant disease, vasculitis, inflammatory bowel syndrome and inflammatory polyradiculopathy. Five (11.11%) cases presented primarily with systemic autoimmune disorders. Biomaterials and prostheses can provoke late-onset systemic autoimmune disorders fulfilling ASIA criteria, or present primarily local/regional inflammatory reactions that may eventually evolve into systemic autoimmune and/or granulomatous disorders which fall under ASIA.
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Registered trials
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