Evidence map›Paper›PMID 29199274›Full record

ReviewEuropean journal of human genetics : EJHG2018

Recent developments in genetics and medically assisted reproduction: from research to clinical applications.

J C Harper, K Aittomäki, P Borry, M C Cornel, G de Wert, W Dondorp, J Geraedts, L Gianaroli, K Ketterson, I Liebaers and 13 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European journal of human genetics : EJHG, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. The use of expanded carrier screening of gamete donors.Human reproduction (Oxford, England) · 2021
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

J C HarperInstitute for Women's Health, University College London, London, UK.
K AittomäkiLaboratory of Genetics, Helsinki University Hospital, Helsinki, Finland.
P BorryDepartment of Public Health and Primary Care, Centre for Biomedical Ethics and Law, KU Leuven, Leuven, Belgium.
M C CornelDepartment of Clinical Genetics, Section Community Genetics, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-5397-5544
G de WertDepartment of Health, Ethics and Society, Research Schools CAPHRI and GROW, Maastricht University, Maastricht, The Netherlands.
W DondorpDepartment of Health, Ethics and Society, Research Schools CAPHRI and GROW, Maastricht University, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0003-4052-7192
J GeraedtsDepartment Genetics and Cell Biology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
L GianaroliS.I.S.Me.R. Reproductive Medicine Unit, Bologna, Italy.
K KettersonAlthea Science, Inc., Livingston, NJ, USA.
I LiebaersCenter for Medical Genetics, UZ Brussels, Brussels, Belgium.
K LundinReproductive Medicine, Sahlgrenska University Hospital, Göteborg, Sweden.
H MertesBioethics Institute Ghent, Department of Philosophy and Moral Science, Ghent University, Ghent, Belgium.
M MorrisSynlab Genetics, Lausanne, Switzerland.
G PenningsBioethics Institute Ghent, Department of Philosophy and Moral Science, Ghent University, Ghent, Belgium.
K SermonResearch Group Reproduction and Genetics, Vrije Universiteit Brussel, Brussels, Belgium.
C SpitsResearch Group Reproduction and Genetics, Vrije Universiteit Brussel, Brussels, Belgium.
S SoiniHelsinki Biobank, Helsinki University Central Hospital, Helsinki, Finland.
A P A van MontfoortIVF Laboratory, Department of Obstetrics & Gynaecology, Maastricht University Medical Center, Maastricht, The Netherlands.
A VeigaBarcelona Stem Cell Bank, Centre of Regenerative Medicine in Barcelona, Hospital Duran i Reynals, Barcelona, Spain.
J R VermeeschDepartment of Human Genetics, KU Leuven, Leuven, Belgium.
S VivilleInstitute of Parasitology and Pathology, University of Strasbourg, Strasbourg, France.
M MacekDepartment of Biology and Medical Genetics, Charles University-2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic. milan.macek.jr@lfmotol.cuni.cz.ORCID http://orcid.org/0000-0002-5173-5280
on behalf of the European Society of Human Reproduction and Embryology and European Society of Human Genetics

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two leading European professional societies, the European Society of Human Genetics and the European Society for Human Reproduction and Embryology, have worked together since 2004 to evaluate the impact of fast research advances at the interface of assisted reproduction and genetics, including their application into clinical practice. In September 2016, the expert panel met for the third time. The topics discussed highlighted important issues covering the impacts of expanded carrier screening, direct-to-consumer genetic testing, voiding of the presumed anonymity of gamete donors by advanced genetic testing, advances in the research of genetic causes underlying male and female infertility, utilisation of massively parallel sequencing in preimplantation genetic testing and non-invasive prenatal screening, mitochondrial replacement in human oocytes, and additionally, issues related to cross-generational epigenetic inheritance following IVF and germline genome editing. The resulting paper represents a consensus of both professional societies involved.

Indexed as

Reproductive Techniques, AssistedCongresses as TopicGenetics, MedicalGenetic TestingHumansAssisted reproductive technologyEpigeneticsExpanded carrier screeningFemale infertilityGamete donor anonymityGermline genome editingMale infertilityMitochondrial replacement therapyNon-invasive prenatal testingPreimplantation genetic testing

Identifiers

PMID29199274
PMCPMC5839000

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.