ReviewProgress in neurobiology
Cerebral venous collaterals: A new fort for fighting ischemic stroke?
Review in Progress in neurobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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The trial behind it
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Who cites it
46 citing papers in PubMed, 79 citations in OpenAlex.
- Quantitative assessment of cerebral venous outflow on routine CT angiography in acute ischemic stroke.European radiology · 2026Article
- Balloon-assisted retrograde cerebral venography for enhanced visualization of the posterior and lateral dural venous sinuses: a feasibility study.Neuroradiology · 2026Article
- Unfavorable clinical outcomes in patients with good collateral scores following endovascular treatment for acute ischemic stroke of the anterior circulation: The UNCLOSE study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Article
- Mediation of ghost infarct core on prognosis by venous outflow and net water uptake after stroke thrombectomy.European radiology · 2026Article
- Deep medullary vein drainage and unfavorable outcomes in stroke patients after endovascular therapy: a retrospective study.BMC neurology · 2026Observational
- Venous return index after mechanical thrombectomy predicts parenchymal hemorrhage and poor outcomes.Journal of neurointerventional surgery · 2026Article
- The angioarchitecture of the vein of Labbé: a population-based-study of 200 Asian hemispheres.Neuroradiology · 2026Article
- The value of multiphase CT angiography in predicting hemorrhagic transformation after endovascular treatment: the arterial collaterals and venous drainage.Quantitative imaging in medicine and surgery · 2026Article
- Quantitative venous outflow profiles based on four-dimensional computed tomography angiography are associated with tissue level collaterals and clinical outcomes of acute ischemic stroke patients.Quantitative imaging in medicine and surgery · 2026Article
- Comprehensive Venous Outflow Evaluation Predicts Stroke Outcome After Optimal Endovascular Ischemic Stroke Treatment.Translational stroke research · 2025Article
- Article
- Dynamic CTA-Based Whole-Brain Arterial-Venous Collateral Assessment for Predicting Futile Recanalization in Acute Ischemic Stroke.Aging and disease · 2025Article
- The microcirculation, the blood-brain barrier, and the neurovascular unit in health and Alzheimer disease: The aberrant pericyte is a central player.Pharmacological reviews · 2025Review
- The Concept of Venous Steal: The Impact of Vascular Stenosis and Outflow Pressure Gradient on Blood Flow Diversion.Medicina (Kaunas, Lithuania) · 2025Review
- Unfavorable venous outflow correlates with poor prognosis in acute ischemic stroke due to large vessel occlusion (AIS-LVO) patients assessed dynamically and quantitatively based on four-dimensional computed tomography angiography/perfusion (4D-CTA/CTP).Quantitative imaging in medicine and surgery · 2025Article
- Key mechanisms of angiogenesis in the infarct core: association of macrophage infiltration with venogenesis.Molecular brain · 2025Article
- Non-Invasive Photoacoustic Cerebrovascular Monitoring of Early-Stage Ischemic Strokes In Vivo.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The benefit of favorable venous outflow profile is mediated through reduced microvascular dysfunction in acute ischemic stroke.European stroke journal · 2024Article
- Cerebral venous congestion alters CNS homeostatic plasticity, evoking tinnitus-like behavior.Cell & bioscience · 2024Article
- Asymmetric deep cerebral venous filling predicts poor outcome of acute basilar artery occlusion after endovascular treatment.CNS neuroscience & therapeutics · 2024Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Stroke therapy has entered a new era highlighted by the use of endovascular therapy in addition to intravenous thrombolysis. However, the efficacy of current therapeutic regimens might be reduced by their associated adverse events. For example, over-reperfusion and futile recanalization may lead to large infarct, brain swelling, hemorrhagic complication and neurological deterioration. The traditional pathophysiological understanding on ischemic stroke can hardly address these occurrences. Accumulating evidence suggests that a functional cerebral venous drainage, the major blood reservoir and drainage system in brain, may be as critical as arterial infusion for stroke evolution and clinical sequelae. Further exploration of the multi-faceted function of cerebral venous system may add new implications for stroke outcome prediction and future therapeutic decision-making. In this review, we emphasize the anatomical and functional characteristics of the cerebral venous system and illustrate its necessity in facilitating the arterial infusion and maintaining the cerebral perfusion in the pathological stroke content. We then summarize the recent critical clinical studies that underscore the associations between cerebral venous collateral and outcome of ischemic stroke with advanced imaging techniques. A novel three-level venous system classification is proposed to demonstrate the distinct characteristics of venous collaterals in the setting of ischemic stroke. Finally, we discuss the current directions for assessment of cerebral venous collaterals and provide future challenges and opportunities for therapeutic strategies in the light of these new concepts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.