ArticleCell systems2018
Widespread Rewiring of Genetic Networks upon Cancer Signaling Pathway Activation.
Article in Cell systems, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Gene regulatory network transitions reveal the central transcription factors in lung adenocarcinoma progression.NPJ systems biology and applications · 2026Article
- Quantitative analysis of genetic interactions in human cells from genome-wide CRISPR-Cas9 screens.bioRxiv : the preprint server for biology · 2026Article
- TransMarker: Unveiling dynamic network biomarkers in cancer progression through cross-state graph alignment and optimal transport.PLoS computational biology · 2025Article
- BaCoN (Balanced Correlation Network) improves prediction of gene buffering.Molecular systems biology · 2025Article
- Gene regulatory networks in disease and ageing.Nature reviews. Nephrology · 2024Review
- Article
- Metabolic pathways, genomic alterations, and post-translational modifications in pulmonary hypertension and cancer as therapeutic targets and biomarkers.Frontiers in pharmacology · 2024Article
- Article
- The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling.Nature communications · 2023Article
- The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6.Nature communications · 2023Article
- A global genetic interaction network by single-cell imaging and machine learning.Cell systems · 2023Article
- A New View of Activating Mutations in Cancer.Cancer research · 2022Article
- Identifying biomarkers for breast cancer by gene regulatory network rewiring.BMC bioinformatics · 2022Article
- Changes in gene-gene interactions associated with cancer onset and progression are largely independent of changes in gene expression.iScience · 2021Article
- A method for benchmarking genetic screens reveals a predominant mitochondrial bias.Molecular systems biology · 2021Article
- CytoTalk: De novo construction of signal transduction networks using single-cell transcriptomic data.Science advances · 2021Article
- Cellular quiescence in budding yeast.Yeast (Chichester, England) · 2021Review
- Review
- Stress Granule Formation Attenuates RACK1-Mediated Apoptotic Cell Death Induced by Morusin.International journal of molecular sciences · 2020Article
- Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.Nature metabolism · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellular signaling networks coordinate physiological processes in all multicellular organisms. Within networks, modules switch their function to control signaling activity in response to the cellular context. However, systematic approaches to map the interplay of such modules have been lacking. Here, we generated a context-dependent genetic interaction network of a metazoan's signaling pathway. Using Wnt signaling in Drosophila as a model, we measured >290,000 double perturbations of the pathway in a baseline state, after activation by Wnt ligand or after loss of the tumor suppressor APC. We found that genetic interactions within the Wnt network globally rewired after pathway activation. We derived between-state networks that showed how genes changed their function between state-specific networks. This related pathway inhibitors across states and identified genes required for pathway activation. For instance, we predicted and confirmed the ER-resident protein Catsup to be required for ligand-mediated Wnt signaling activation. Together, state-dependent and between-state genetic interaction networks identify responsive functional modules that control cellular pathways.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.