ArticleCell stem cell2017
Bone Marrow Myeloid Cells Regulate Myeloid-Biased Hematopoietic Stem Cells via a Histamine-Dependent Feedback Loop.
Open access · bronzeAbstract read
In one paragraph
Article in Cell stem cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed, 101 citations in OpenAlex.
- Histamine receptor 2 blockade selectively impacts B and T cells in healthy subjects.Scientific reports · 2021Trial
- Sympathetic signaling activation alleviated acute respiratory distress syndrome via the HDC/SLC7A11 axis in lipopolysaccharide-induced macrophages.Cell death discovery · 2026Article
- Article
- New Insights Into the Role of Neutrophils in Lymphoma.Cancer medicine · 2026Review
- Histidine alleviates Hashimoto's thyroiditis via the neutrophil extracellular traps-NF-κB signaling pathway.Scientific reports · 2026Article
- Chronic stress promotes pancreatic ductal adenocarcinoma progression via complement C5a-recruited myeloid-derived suppressor cells.Cancer immunology, immunotherapy : CII · 2025Article
- Bone marrow neutrophil density regulates myelopoiesis during obesity and weight loss.The Journal of experimental medicine · 2025Article
- A CXCR4 partial agonist improves immunotherapy by targeting immunosuppressive neutrophils and cancer-driven granulopoiesis.Cancer cell · 2025Article
- Restoring resident tissue macrophages to combat aging and cancer.Nature aging · 2025Review
- Neutrophil Spatiotemporal Regulatory Networks: Dual Roles in Tumor Growth Regulation and Metastasis.Biomedicines · 2025Review
- Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells.Nature aging · 2025Article
- High fat diet feeding impairs neutrophil phagocytosis, bacterial killing, and neutrophil-induced hematopoietic regeneration.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Reducing functionally defective old HSCs alleviates aging-related phenotypes in old recipient mice.Cell research · 2025Article
- Effect of bone marrow niche on hematopoietic stem cells.Histochemistry and cell biology · 2024Review
- The role of immune cells settled in the bone marrow on adult hematopoietic stem cells.Cellular and molecular life sciences : CMLS · 2024Review
- Cell-type-specific consequences of mosaic structural variants in hematopoietic stem and progenitor cells.Nature genetics · 2024Article
- PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Microbial-Dependent Recruitment of Immature Myeloid Cells Promotes Intestinal Regeneration.Cellular and molecular gastroenterology and hepatology · 2024Article
- Hematopoietic stem cells undergo a lymphoid to myeloid switch in early stages of emergency granulopoiesis.The EMBO journal · 2023Article
- Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity.Nature reviews. Molecular cell biology · 2023Review
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
35 authors at 8 institutions in 6 countries.
Xiaowei ChenDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA; Division of Hematology/Oncology, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Huan DengDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA; Division of Hematology/Oncology, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA; Department of Pathology and Molecular Medicine and Genetics Center, The Fourth Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330003, China.
Michael J ChurchillDivision of Hematology/Oncology, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.
Larry L LuchsingerColumbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA; Center for Human Development, Columbia University Medical Center, New York, NY 10032, USA.
Xing DuDivision of Hematology/Oncology, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.
Timothy H ChuDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Richard A FriedmanHerbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA; Biomedical Informatics Shared Resource, Herbert Irving Comprehensive Cancer Center, and Department of Biomedical Informatics, Columbia University Medical Center, New York, NY 10032, USA.
Moritz MiddelhoffDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Hongxu DingBiomedical Informatics Shared Resource, Herbert Irving Comprehensive Cancer Center, and Department of Biomedical Informatics, Columbia University Medical Center, New York, NY 10032, USA; Department of Systems Biology, Columbia University, New York, NY 10032, USA.
Yagnesh H TailorDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Alexander L E WangDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Haibo LiuDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Zhengchuan NiuDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Hongshan WangDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Zhengyu JiangDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Simon RendersDivision of Hematology/Oncology, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA; Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance and Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany.
Siu-Hong HoColumbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA.
Spandan V ShahColumbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA.
Pavel TishchenkoColumbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA.
Wenju ChangDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Theresa C SwayneHerbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Laura MunteanuHerbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Andrea CalifanoBiomedical Informatics Shared Resource, Herbert Irving Comprehensive Cancer Center, and Department of Biomedical Informatics, Columbia University Medical Center, New York, NY 10032, USA; Department of Systems Biology, Columbia University, New York, NY 10032, USA.
Ryota TakahashiDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Karan K NagarDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Bernhard W RenzDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA; Department of General, Visceral and Transplantation Surgery, Hospital of the University of Munich, 81377 Munich, Germany.
Daniel L WorthleyDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA; School of Medicine, University of Adelaide, Adelaide, SA 5005, Australia; Cancer Theme, SAHMRI, Adelaide, SA 5005, Australia.
C Benedikt WestphalenDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA; Department of Medicine III, University Hospital, LMU Munich, 81377 Munich, Germany.
Yoku HayakawaDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA; Department of Gastroenterology, Graduate School of Medicine, the University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Samuel AsfahaDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA; Department of Medicine, University of Western Ontario, London, ON N6A 5W9, Canada.
Florence BorotDivision of Hematology/Oncology, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.
Chyuan-Sheng LinHerbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA.
Hans-Willem SnoeckColumbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032, USA; Center for Human Development, Columbia University Medical Center, New York, NY 10032, USA; Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.
Siddhartha MukherjeeDivision of Hematology/Oncology, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA. Electronic address: sm3252@columbia.edu.
Timothy C WangDivision of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA. Electronic address: tcw21@columbia.edu.
Columbia University Irving Medical Center · USColumbia University · USThe First Affiliated Hospital, Sun Yat-sen University · CNDKFZ-ZMBH Alliance · DELudwig-Maximilians-Universität München · DESouth Australian Health and Medical Research Institute · AUSun Yat-sen University · CNThe University of Tokyo · JP
Funding
Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Parisa Tehranifar · 1985 to 2026
$115.3MPredicting Cancer Cell Response to Endogenous and Exogenous Perturbations at the Single Cell LevelR35CA197745 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ANDREA CALIFANO · 2015 to 2026
$11.5MTHE FUNCTION AND REGULATION OF HISTIDINE DECARBOXYLASE IN GUT INFLAMMATIONR01DK048077 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WANG, TIMOTHY CRAGIN · 1995 to 2020
$5.9MMitochondrial Regulation of Hematopoietic Stem CellsR01HL135039 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SNOECK, HANS-WILLEM E · 2017 to 2025
$4.5MHigh-performance compute cluster for biomedical computingS10OD012351 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CALIFANO, ANDREA · 2012 to 2012
$2.0MYes1 as a quiescence regulator in hematopoietic stem cellsR01HL115145 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MUKHERJEE, SIDDHARTHA · 2013 to 2017
$2.0MMitochondrial Maintenance Mechanisms of Stem Cells and AgingR01AG055910 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SNOECK, HANS-WILLEM E · 2017 to 2021
$2.0MBD Biosciences InfluxS10OD020056 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SNOECK, HANS-WILLEM E · 2015 to 2015
$600kStorage System for High Performance ComputingS10OD021764 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CALIFANO, ANDREA · 2016 to 2016
$600kBecton Dickinson LSR II Analytical Flow CytometerS10RR027050 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLYNES, RAPHAEL A. · 2011 to 2011
$413kNCI NIH HHS P30 CA013696NCI NIH HHS R35 CA197745NCRR NIH HHS S10 RR027050NHLBI NIH HHS R01 HL115145NHLBI NIH HHS R01 HL135039NIA NIH HHS R01 AG055910NIDDK NIH HHS R01 DK048077NIH HHS S10 OD012351NIH HHS S10 OD020056NIH HHS S10 OD021764
Abstract
Myeloid-biased hematopoietic stem cells (MB-HSCs) play critical roles in recovery from injury, but little is known about how they are regulated within the bone marrow niche. Here we describe an auto-/paracrine physiologic circuit that controls quiescence of MB-HSCs and hematopoietic progenitors marked by histidine decarboxylase (Hdc). Committed Hdc
Indexed as
AnimalsBone MarrowBone Marrow TransplantationFlow CytometryHematopoietic Stem CellsHistamineLipopolysaccharidesMiceMyeloid CellsHistamineLipopolysaccharidesbone marrow nicheH2 receptorhematopoietic stem cellshistaminehistidine decarboxylasemyeloid biasedquiescenceself-renewal
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