ArticleJournal of the American Academy of Dermatology2018
Mitotic rate is associated with positive lymph nodes in patients with thin melanomas.
Article in Journal of the American Academy of Dermatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- An Evaluation of Sentinel Lymph Node Biopsy Guideline Adherence in Melanoma.Annals of surgical oncology · 2025Article
- Integrating the melanoma 31-gene expression profile test with clinical and pathologic features can provide personalized precision estimates for sentinel lymph node positivity: an independent performance cohort.World journal of surgical oncology · 2024Article
- Invasive Cutaneous Melanoma: Evaluating the Prognostic Significance of Some Parameters Associated with Lymph Node Metastases.Medicina (Kaunas, Lithuania) · 2023Article
- Predictors of Nodal Metastasis in Cutaneous Head and Neck Cancers.Current oncology reports · 2022Review
- Predictive accuracy of elevated mitotic rate on lymph node positivity and recurrence in thin melanomas.Frontiers in oncology · 2022Article
- Integrating 31-Gene Expression Profiling With Clinicopathologic Features to Optimize Cutaneous Melanoma Sentinel Lymph Node Metastasis Prediction.JCO precision oncology · 2021Article
- Genotoxic potential of a novel PDE-4B inhibitor Apremilast by chromosomal aberration and micronucleus assay in mice.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2020Article
- Article
- Distinct Clinicopathological and Prognostic Features of Thin Nodular Primary Melanomas: An International Study from 17 Centers.Journal of the National Cancer Institute · 2019Article
- Mitotic rate as an important prognostic factor in cutaneous malignant melanoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2019Observational
- Survival analysis and sentinel lymph node status in thin cutaneous melanoma: A multicenter observational study.Cancer medicine · 2019Observational
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundThe American Joint Commission on Cancer will remove mitotic rate from its staging guidelines in 2018.
objectiveUsing a large nationally representative cohort, we examined the association between mitotic rate and lymph node positivity among thin melanomas.
methodsA total of 149,273 thin melanomas in the National Cancer Database were examined for their association of high-risk features of mitotic rate, ulceration, and Breslow depth with lymph node status.
resultsAmong 17,204 patients with thin melanomas with data on Breslow depth, ulceration, and mitotic rate who underwent a lymph node biopsy, there was a strong linear relationship between odds of having a positive lymph node and mitotic rate (R LIMITATIONS: The data collected do not allow for survival analyses.
conclusionsMitotic rate was strongly associated with the odds of having a positive lymph node and should continue to be reported on pathology reports.
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