ArticleAmerican journal of human genetics2017
Multiethnic GWAS Reveals Polygenic Architecture of Earlobe Attachment.
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In one paragraph
Article in American journal of human genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 9% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Combined genome-wide association study of 136 quantitative ear morphology traits in multiple populations reveal 8 novel loci.PLoS genetics · 2023Pooled it
- A Prospective Analysis of Genetic Variants Associated with Human Lifespan.G3 (Bethesda, Md.) · 2019Pooled it
- Quantitative and Qualitative Evaluation of the Sweating Function of the Human Earlobe for Heat Stress Monitoring.Safety and health at work · 2026Article
- Exploration of the auricle morphology of young adults from 10 countries.Scientific reports · 2026Article
- Ear biometrics in forensic identification: from ear similarity quantification to kinship verification driven by deep learning approaches.International journal of legal medicine · 2026Article
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- Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity.bioRxiv : the preprint server for biology · 2025Article
- Exploring the association between SNPs and facial morphology in a Spanish population.Scientific reports · 2025Article
- DNA-based prediction of external ear morphology in the Chinese population: an exploratory study.PeerJ · 2025Article
- Evaluation of loci to predict ear morphology using two SNaPshot assays.Forensic science, medicine, and pathology · 2023Article
- Noncoding SNP at rs1663689 represses ADGRG6 via interchromosomal interaction and reduces lung cancer progression.EMBO reports · 2023Article
- Comparative Genomic and Transcriptomic Analyses Reveal the Impacts of Genetic Admixture in Kazaks, Uyghurs, and Huis.Molecular biology and evolution · 2023Article
- Potential risk factors and genetic variants associated with dental caries incidence in Appalachia using genome-wide survival analysis.International journal of molecular epidemiology and genetics · 2023Article
- An ancient founder mutation located betweenProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Genetic variants underlying differences in facial morphology in East Asian and European populations.Nature genetics · 2022Article
- Evidence for shared genetic risk factors between lymphangioleiomyomatosis and pulmonary function.ERJ open research · 2022Article
- Evidence of Selection in the Ectodysplasin Pathway among Endangered Aquatic Mammals.Integrative organismal biology (Oxford, England) · 2022Article
- Novel genetic associations with five aesthetic facial traits: A genome-wide association study in the Chinese population.Frontiers in genetics · 2022Article
- Prioritising positively selected variants in whole-genome sequencing data using FineMAV.BMC bioinformatics · 2021Article
- EDAR, LYPLAL1, PRDM16, PAX3, DKK1, TNFSF12, CACNA2D3, and SUPT3H gene variants influence facial morphology in a Eurasian population.Human genetics · 2019Article
Corrections and comments
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Authors and funding
32 authors at 16 institutions in 11 countries.
John R ShafferDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Jinxi LiChinese Academy of Sciences Key Laboratory of Computational Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Myoung Keun LeeCenter for Craniofacial and Dental Genetics, Department of Oral Biology, University of Pittsburgh, Pittsburgh, PA 15219, USA.
Jasmien RoosenboomCenter for Craniofacial and Dental Genetics, Department of Oral Biology, University of Pittsburgh, Pittsburgh, PA 15219, USA.
Ekaterina OrlovaDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Kaustabh AdhikariDepartment of Genetics, Evolution and Environment, University College London, London, UK.
23andMe Research Team23andMe Inc., 899 West Evelyn Avenue, Mountain View, CA 94041, USA.
Carla GalloLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, 430 Cercado de Lima, Peru.
Giovanni PolettiLaboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, 430 Cercado de Lima, Peru.
Lavinia Schuler-FacciniDepartamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre 90040-060, Brazil.
Maria-Cátira BortoliniDepartamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre 90040-060, Brazil.
Samuel Canizales-QuinterosUnidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, Universidad Nacional Autónoma de México, Instituto Nacional de Medicina Genómica, Mexico City 4510, Mexico.
Francisco RothhammerInstituto de Alta Investigación, Universidad de Tarapacá, Arica, Chile; Facultad de Medicina, Universidad de Chile, Santiago 8320000, Chile.
Gabriel BedoyaGrupo Genética Molecular GENMOL, Universidad de Antioquia, Medellín 050003, Colombia.
Rolando González-JoséInstituto Patagónico de Ciencias Sociales y Humanas, Centro Científico Tecnológico, Centro Nacional Patagónico, Consejo Nacional de Investigaciones Científicas y Técnicas, Puerto Madryn U9120, Argentina.
Paige E PfefferCenter for Advanced Dental Education, Orthodontics Program, Saint Louis University, St. Louis, MO 63104, USA.
Christopher A WollenschlaegerDepartment of Orthodontics, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Jacqueline T HechtDepartment of Pediatrics, McGovern Medical School, University of Texas, Houston, TX 77030, USA.
George L WehbyDepartment of Health Management and Policy, University of Iowa, Iowa City, IA 52246, USA.
Lina M MorenoDepartment of Orthodontics, University of Iowa, Iowa City, IA 52242, USA.
Anan DingChinese Academy of Sciences Key Laboratory of Computational Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Li JinChinese Academy of Sciences Key Laboratory of Computational Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China; Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200433, China.
Yajun YangMinistry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200433, China.
Jenna C CarlsonDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Elizabeth J LeslieCenter for Craniofacial and Dental Genetics, Department of Oral Biology, University of Pittsburgh, Pittsburgh, PA 15219, USA.
Eleanor FeingoldDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Mary L MarazitaDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA; Center for Craniofacial and Dental Genetics, Department of Oral Biology, University of Pittsburgh, Pittsburgh, PA 15219, USA; Clinical and Translational Science Institute, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
David A Hinds23andMe Inc., 899 West Evelyn Avenue, Mountain View, CA 94041, USA.
Timothy C CoxCenter for Developmental Biology & Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA 98101, USA; Craniofacial Medicine, Department of Pediatrics, University of Washington, Seattle, WA 98195, USA; Department of Anatomy & Developmental Biology, Monash University, Clayton, VIC 3800, Australia.
Sijia WangChinese Academy of Sciences Key Laboratory of Computational Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China; Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200433, China. Electronic address: wangsijia@picb.ac.cn.
Andrés Ruiz-LinaresDepartment of Genetics, Evolution and Environment, University College London, London, UK; Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200433, China; Laboratory of Biocultural Anthropology, Law, Ethics, and Health, Centre National de la Recherche Scientifique and Etablissement Français du Sang, UMR 7268, Aix-Marseille University, Marseille 13284, France.
Seth M WeinbergDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA; Center for Craniofacial and Dental Genetics, Department of Oral Biology, University of Pittsburgh, Pittsburgh, PA 15219, USA; Department of Anthropology, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address: smwst46@pitt.edu.
University of Pittsburgh · US23andMe (United States) · USFudan University · CNUniversidade Federal do Rio Grande do Sul · BRUniversidad Peruana Cayetano Heredia · PEUniversity College London · GBUniversity of Chinese Academy of Sciences · CNUniversity of Iowa · USCentro Científico Tecnológico Patagónico · ARMonash University · AUSaint Louis University · USShanghai Institutes for Biological Sciences · CNThe University of Texas Health Science Center at Houston · USUniversidad de Antioquia · COUniversidad Nacional Autónoma de México · MXUniversity of Tarapacá · CL
Funding
Extending the Phenotype of Nonsyndromic Orofacial CleftsR01DE016148 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARAZITA, MARY L., WEINBERG, SETH M · 2004 to 2018
$19.7MFaceBase Management and Coordination HubU01DE020057 · NIDCR · UNIVERSITY OF IOWA · PI MARAZITA, MARY L., MURRAY, JEFFREY C · 2009 to 2014
$8.9MThe Genetic Architecture of Human Facial MorphologyR01DE027023 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CLAES, PETER, SHAFFER, JOHN R · 2017 to 2024
$5.2MGenetic and developmental pathways causing midface hypoplasiaR01DE022561 · NIDCR · SEATTLE CHILDREN'S HOSPITAL · PI COX, TIMOTHY CHILTON · 2012 to 2016
$3.3M3D Analysis of Normal Facial Variation: Data Repository and Genetics (Research)U01DE020078 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARAZITA, MARY L., WEINBERG, SETH M · 2009 to 2013
$2.0MGenetics of Craniofacial Disorders and Related PhenotypesR00DE025060 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LESLIE-CLARKSON, ELIZABETH JANE · 2017 to 2019
$732kDevelopment and Application of Phenome-wide Scan of Heritability (PheSH)K22LM011938 · NLM · MARSHFIELD CLINIC RESEARCH FOUNDATION · PI HEBBRING, SCOTT JOSEPH · 2014 to 2016
$405kNCBDD CDC HHS R01 DD000295NHLBI NIH HHS HHSN268201200008CNHLBI NIH HHS HHSN268201200008INIDCR NIH HHS R00 DE025060NIDCR NIH HHS R01 DE016148NIDCR NIH HHS R01 DE022561NIDCR NIH HHS R01 DE027023NIDCR NIH HHS U01 DE020057NIDCR NIH HHS U01 DE020078NLM NIH HHS K22 LM011938
Abstract
The genetic basis of earlobe attachment has been a matter of debate since the early 20
Indexed as
AdolescentAdultAnimalsBranchial RegionChildChild, PreschoolDNA-Binding ProteinsEarEdar ReceptorGenome-Wide Association StudyGenotypeHumansMiceMiddle AgedMitochondrial ProteinsMultifactorial InheritanceADGRG6 protein, humanDNA-Binding ProteinsEDAR protein, humanEdar ReceptorKIAA1217 protein, humanMitochondrial ProteinsMRPS22 protein, humanPAX9 protein, humanPAX9 Transcription FactorProteinsReceptors, G-Protein-CoupledRibosomal ProteinsSP5 protein, humanTranscription Factorsattached earlobecomplex trait geneticsepistasisgenome-wide association studymultigenicpharyngeal archpinnatrans-ethnicunattached earlobe
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