ArticleAddictive behaviors2018
Overdose and adverse drug event experiences among adult patients in the emergency department.
Article in Addictive behaviors, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Opioid Misuse and Suicide-Related Outcomes Among Adolescents and Young Adults: A Systematic Review.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2025Pooled it
- Psychosocial factors associated with overdose subsequent to Illicit Drug use: a systematic review and narrative synthesis.Harm reduction journal · 2024Pooled it
- Collaborative care intervention for risky opioid use among primary care patients: The STOP randomized clinical trial.Addiction (Abingdon, England) · 2026Trial
- Understanding the characteristics and comorbidities of primary care patients with risky opioid use: Baseline data from the multi-site "Subthreshold Opioid Use Disorder Prevention" (STOP) Trial.Journal of general internal medicine · 2025Trial
- Links between suicidal intent, polysubstance use, and medical treatment after non-fatal opioid overdose.Drug and alcohol dependence · 2020Trial
- From description to clinical impact: Critical gaps in the evaluation of drug intoxication in the emergency department.Northern clinics of Istanbul · 2026Article
- Cross sectional multi-sample study of nonfatal overdose in adolescents and young adults in the fentanyl era.Drug and alcohol dependence · 2025Article
- Naloxone Use, 911 Calls, and Emergency Visits After Nonfatal Overdose.JAMA network open · 2025Article
- Physiologically Based Pharmacokinetic Modeling to Predict Lamotrigine Exposure in Special Populations to Facilitate Therapeutic Drug Monitoring and Guide Dosing Regimens.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Drug intoxications in the emergency department: Our 1-year experience.Northern clinics of Istanbul · 2025Article
- Associations of medical outcomes with substances involved in suicide attempt cases age 50 and older reported to U.S. Poison Centers, 2016-2023.Frontiers in public health · 2025Observational
- Health-related outcomes among veterans identified as being at increased risk during a crisis line contact.Psychological services · 2024Article
- Subthreshold opioid use disorder prevention (STOP) trial: a cluster randomized clinical trial: study design and methods.Addiction science & clinical practice · 2023Article
- Iatrogenic Side Effects of Pain Therapies.Cureus · 2023Review
- From Bumps to Binges: Overview of Deaths Associated with Cocaine in England, Wales and Northern Ireland (2000-2019).Journal of analytical toxicology · 2023Article
- High suicidality predicts overdose events among people with substance use disorder: A latent class analysis.Frontiers in public health · 2023Article
- Prevalence and correlates of using opioids alone among individuals in a residential treatment program in Michigan: implications for overdose mortality prevention.Harm reduction journal · 2022Article
- Suicidality as a Predictor of Overdose among Patients with Substance Use Disorders.Journal of clinical medicine · 2022Article
- Characteristics of events in which police responded to overdoses: an examination of incident reports in Rhode Island.Harm reduction journal · 2022Article
- Profiles of Patients with Opioid Use Disorders Presenting a History of Suicidal Ideations and Attempts.The Psychiatric quarterly · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
introductionOverdose is a leading cause of injury and death in the United States. Emergency Department (ED) patients have an elevated prevalence of substance use. This study describes overdose/adverse drug event experiences among adult ED patients to inform strategies to address overdose risk.
methodsPatients seeking care at a large ED in the city of Flint, Michigan participated in a computerized self-assessment during 2011-2013 (n=4571). Overdose was assessed with a broad definition and included occurrences that could be considered adverse drug events. Among those with this type of experience, additional items assessed symptoms, outcomes, and intent.
results12% reported an overdose history. Of participants' most serious overdoses, 74% were without clear intent for self-harm, although this was true of only 61% of overdoses involving opiates or sedatives, and 52% had symptoms present that indicated that it was life-threatening. Binge drinking on a monthly basis (ORs=1.4) was associated with a medically serious overdose compared to never having an overdose. Compared to no drug use in the last year, use of one drug was associated with an OR of 1.8, two drugs was associated with an OR of 5.8, three drugs was associated with an OR of 8.4, and four or more drugs was associated with an OR of 25.1 of having had a medically serious overdose (all p<0.05).
conclusionsMost overdose experiences among ED patients were without clear intent of self-harm. The ED may be an appropriate setting for efforts to reduce overdose risk, especially among polysubstance users.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.