Evidence map›Paper›PMID 29198450›Full record

ArticleClinical therapeutics2018

Effects of Exercise on Non-motor Symptoms in Parkinson's Disease.

Amy W Amara, Adeel A Memon

3 registry-linked trialsOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 58 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04012086 nacompletednot on this map

Intensive Physical Therapy Mitigates Cognitive Decline in People With Parkinson's Disease

TypeinterventionalSponsorIRCCS National Neurological Institute "C. Mondino" FoundationRan2015 to 2018Enrolled40ConditionsParkinson Disease, Cognitive ImpairmentArmsPhysical therapy
NCT04267107 nacompletednot on this mapstarted 2020, after this paper: background citation

Managing Fatigue: The Individual Program in People Living With Parkinson's Disease- A Protocol for a Feasibility Study

TypeinterventionalSponsorDalhousie UniversityRan2020 to 2022Enrolled23ConditionsParkinson DiseaseArmsIndividual Managing Fatigue Program
NCT07221266 narecruitingnot on this mapstarted 2026, after this paper: background citation

Changes in Motor Function, Quality of Life, Cardiorespiratory Fitness, and Physiological Markers in People With Parkinson's Disease Following Different Exercise Interventions.

TypeinterventionalSponsorUniversity of Texas, El PasoRan2026 to 2027Enrolled45ConditionsParkinson Disease (PD)ArmsGuided Cycling, Non-Contact Boxing, Traditional Physical Therapy Program (Standard of Care)
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 2 syntheses or guidelines pooled it, 108 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Randomized, Controlled Trial of Exercise on Objective and Subjective Sleep in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2020
    Trial
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Therapeutic Mechanisms of Exercise in Parkinson's Disease.International journal of molecular sciences · 2025
    Review
  15. Nutritional and dietary clinical trials for Parkinson's disease: a narrative review.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
  16. Article
  17. Review
  18. Lessons Learned from a Parkinson's Research Patient Advisory Board Model with Academic Centers.Progress in community health partnerships : research, education, and action · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Amy W AmaraDepartment of Neurology, University of Alabama at Birmingham, Birmingham, Alabama. Electronic address: amyamara@uab.edu.
Adeel A MemonDepartment of Neurology, University of Alabama at Birmingham, Birmingham, Alabama.
University of Alabama at Birmingham · US

Funding

Pilot CoreP30AG022838 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BALL, KARLENE K · 2003 to 2020
$5.7M
The Effect of Low Frequency STN DBS on Sleep and Vigilance in PD PatientsK23NS080912 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMARA, AMY WILLIS · 2012 to 2016
$934k
NIA NIH HHS P30 AG022838NINDS NIH HHS K23 NS080912
6 · The paper itself

Abstract

Patients with Parkinson's disease experience disabling non-motor symptoms, including autonomic dysfunction, cognitive decline, and sleep disorders. Pharmacologic treatments for these symptoms are often ineffective or have intolerable side effects. Therefore, non-pharmacologic interventions are an attractive alternative. Exercise in particular has the potential to alleviate the progressive impairment related to these non-motor symptoms. In this commentary, we explore available research that addresses the impact of exercise and physical activity on autonomic dysfunction, cognitive impairment, and sleep disorders in Parkinson's disease and suggest areas in need of further study. Many gaps remain in our understanding of the most effective exercise intervention for these symptoms, the mechanisms underlying exercise-induced changes, and the best way to monitor response to therapy. However, available research suggests that exercise is a promising approach to improve non-motor symptoms in patients with Parkinson's disease.

Indexed as

Exercise TherapyCognitive DysfunctionHumansParkinson DiseaseSleep Wake Disordersautonomic functioncognitionexercisenon-motor symptomsParkinson’s diseasesleep

Identifiers

PMID29198450
PMCPMC5875718
OpenAlexW2775036247

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.