ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2018
Neurobehavioral Impairment and CPAP Treatment Response in Mild-Moderate Obstructive Sleep Apneas.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Educational, supportive and behavioural interventions to improve usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea.The Cochrane database of systematic reviews · 2020Pooled it
- Positional therapy for obstructive sleep apnoea.The Cochrane database of systematic reviews · 2019Pooled it
- Effects of Medical Therapy on Mild Obstructive Sleep Apnea in Adult Patients.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Trial
- Beyond the apnea-hypopnea index: a call to action for a multidimensional evaluation in obstructive sleep apnea.Frontiers in sleep · 2026Article
- The Global Burden of Obstructive Sleep Apnea.Diagnostics (Basel, Switzerland) · 2025Review
- Evaluating Somfit's pulse arterial tonometry for detection of obstructive sleep apnoea.Sleep and biological rhythms · 2025Article
- Melatonin and Cortisol Concentration Before and After CPAP Treatment of Obstructive Sleep Apnea.Nature and science of sleep · 2025Article
- Article
- Obstructive Sleep Apnea - Influence on the Cardiovascular System and Cognition.Laryngo- rhino- otologie · 2023Article
- Integrative Analysis and Experimental Validation of Competing Endogenous RNAs in Obstructive Sleep Apnea.Biomolecules · 2023Article
- The Effect of Obstructive Sleep Apnea on Sleep-dependent Emotional Memory Consolidation.Annals of the American Thoracic Society · 2023Article
- Article
- Changes in sleepiness and 24-h blood pressure following 4 months of CPAP treatment are not mediated by ICAM-1.Sleep & breathing = Schlaf & Atmung · 2021Observational
- Continuous Positive Airway Pressure Restores Declarative Memory Deficit in Obstructive Sleep Apnea.American journal of respiratory and critical care medicine · 2021Article
- Electroencephalographic Activity and Cognitive Function in Middle-Aged Patients with Obstructive Sleep Apnea Before and After Continuous Positive Airway Pressure Treatment.Nature and science of sleep · 2021Article
- Obstructive Sleep Apnea and Its Treatment in Aging: Effects on Alzheimer's disease Biomarkers, Cognition, Brain Structure and Neurophysiology.Neurobiology of disease · 2020Review
- Integrity of Multiple Memory Systems in Individuals With Untreated Obstructive Sleep Apnea.Frontiers in neuroscience · 2020Article
- Psychomotor Performance in Patients with Obstructive Sleep Apnea Syndrome.Nature and science of sleep · 2020Article
- Anxiety and Depression in Patients with Obstructive Sleep Apnoea before and after Continuous Positive Airway Pressure: The ADIPOSA Study.Journal of clinical medicine · 2019Article
- Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesThe degree of neurobehavioral impairment and treatment response in mild-moderate obstructive sleep apnea (OSA) compared to that of an appropriate control group are unclear. This study compared neurobehavioral function and response to continuous positive airway pressure (CPAP) treatment in patients with mild to moderate OSA with those of a non-sleep apneic community sample of similar demography.
methodsOne hundred ten patients with OSA and 31 asymptomatic community dwellers underwent overnight polysomnography and neurobehavioral testing. Participants with OSA (n = 88) were treated with CPAP for 3 months, and repeat evaluations were performed at the end of the treatment period.
resultsCompared to the community sample, participants with OSA were significantly sleepier, had impaired mood and quality of life, and showed decrements in neuropsychological function, specifically psychomotor function, working memory and vigilance. Some neuropsychological and mood outcomes were normalized with CPAP, but significant decrements persisted in most outcomes even in those participants with adequate device usage.
conclusionsPatients with mild to moderate OSA have significant neurobehavioral morbidity. During "gold standard" treatment, normal function was not achieved, even with adequate device usage. CPAP efficacy for improving sleepiness and neuropsychological function in this milder end of the OSA spectrum may be poor, which may affect CPAP adherence. These findings suggest that there may be neurological changes related to OSA that do not respond to CPAP treatment, the etiology of which requires further investigation.
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