ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2018
The MSLT is Repeatable in Narcolepsy Type 1 But Not Narcolepsy Type 2: A Retrospective Patient Study.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Machine Learning for Diagnosis and Differentiation of Central Disorders of Hypersomnolence: A Systematic Review.European journal of neurology · 2026Pooled it
- Modafinil Versus Amphetamine-Dextroamphetamine For Idiopathic Hypersomnia and Narcolepsy Type 2: A Randomized, Blinded, Non-inferiority Trial.CNS drugs · 2024Trial
- Trial
- Article
- Therapeutic potential of targeting the orexin (hypocretin) system in sleep disorders.Nature reviews. Endocrinology · 2026Review
- Reply to "Unexpectedly higher mortality in non‑type 1 narcolepsy: diagnostic heterogeneity or unmeasured confounders?"Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Polysomnographic and Clinical Characteristics of Narcolepsy in Saudi Arabia:Saudi medical journal · 2026Article
- Article
- Research priorities to improve classification of sleep-wake disorders.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Review
- Clinical significance of nocturnal sleep onset REM periods in narcolepsy diagnosis and diagnostic stability.Sleep and biological rhythms · 2026Article
- Idiopathic hypersomnia is a 24-hour disorder.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Review
- Predictors of Sleep Latency From the Multiple Sleep Latency Test: A Random Forest Investigation in a Community Sample.Journal of sleep research · 2025Article
- Present and Future of Central Disorders of Hypersomnolence.Journal of sleep research · 2025Review
- Current knowledge on the pathophysiology of idiopathic hypersomnia and potential mechanisms of action for low-sodium oxybate treatment.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Review
- Narcolepsy and rapid eye movement sleep.Journal of sleep research · 2025Review
- Circadian Modulation of Sleep-Wake Behavior in Patients with Narcolepsy Type 1 and Idiopathic Hypersomnia.Nature and science of sleep · 2025Article
- Identifying time-resolved features of nocturnal sleep characteristics of narcolepsy using machine learning.Journal of sleep research · 2024Article
- Insights from a 10-year Australasian idiopathic hypersomnia patient data registry study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Validation and performance of the sleep inertia questionnaire in central disorders of hypersomnolence.Sleep medicine · 2024Article
- Exploring sleep characteristics in Chinese patients with narcolepsy: insights from the nocturnal sleep onset rapid eye movement period (nSOREMP).Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
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Authors and funding
15 authors.
Funding
Abstract
STUDY
objectivesTo examine repeatability of Multiple Sleep Latency Test (MSLT) results in narcolepsy type 1 (NT1) and narcolepsy type 2 (NT2) according to the criteria of the International Classification of Sleep Disorders, Third Edition (ICSD-3).
methodsRepeatability of the MSLT was retrospectively evaluated in NT1 (n = 60) and NT2 (n = 54) cases, and controls (n = 15). All subjects had documented HLA-DQB1*06:02 status and/or hypocretin-1 levels from cerebrospinal fluid. All subjects had undergone 2 MSLTs (≥ 1 meeting ICSD-3 criteria for narcolepsy). Repeatability was explored in children versus adults and in those on versus not on medication(s). Subsample and multivariate analysis were performed.
resultsBoth MSLTs in unmedicated patients were positive for narcolepsy in 78%, 18%, and 7% of NT1, NT2, and controls, respectively. NT2 cases changed to idiopathic hypersomnia or to a negative MSLT 26% and 57% of the time, respectively. Although NT1 cases were 10 to 14 times more likely to demonstrate a second positive MSLT compared to NT2 cases (
conclusionsIn a clinical setting, a positive MSLT for narcolepsy is a more reproducible and stable feature in NT1 than NT2. The retrospective design of this study hinders interpretation of these data, as there are many different, and possibly opposing, reasons to repeat a MSLT in NT1 versus NT2 (ie, ascertainment bias). Additional systematic MSLT repeatability studies independent of confounds are ideally needed to confirm these findings.
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