ArticleInternational psychogeriatrics2018
Presence of neuroticism and antidepressant remission rates in late-life depression: results from the Neurobiology of Late-Life Depression (NBOLD) study.
Article in International psychogeriatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- State of the Science of Neural Systems in Late-Life Depression: Impact on Clinical Presentation and Treatment Outcome.Journal of the American Geriatrics Society · 2018Pooled it
- Modifiable predictors of suicidal ideation during psychotherapy for late-life major depression. A machine learning approach.Translational psychiatry · 2021Trial
- Modifiable predictors of nonresponse to psychotherapies for late-life depression with executive dysfunction: a machine learning approach.Molecular psychiatry · 2021Trial
- Moderators of treatment response in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Do Adult Attachment Style or Personality Mediate the Relationship Between Childhood Maltreatment and Late-Life Depression in Poor Communities?Journal of geriatric psychiatry and neurology · 2023Article
- Effects of Longitudinal Changes in Neuroticism and Stress on Cognitive Decline.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023Observational
- Interactions between neuroticism and stressful life events predict response to pharmacotherapy for major depression: A CAN-BIND 1 report.Personality and mental health · 2021Article
- Mediation model of comorbid anxiety disorders in late-life depression.Annals of general psychiatry · 2020Article
- Depressive symptomatology and personality traits in patients with symptomatic and asymptomatic peripheral arterial disease.BMC cardiovascular disorders · 2020Article
- Prevalence of affective disorders and dementia in inflammatory polyarthropathies.European archives of psychiatry and clinical neuroscience · 2020Article
- The role of perceived stress and cognitive function on the relationship between neuroticism and depression among the elderly: a structural equation model approach.BMC psychiatry · 2020Article
- Functional connectivity predictors of acute depression treatment outcome.International psychogeriatrics · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
ABSTRACTNeuroticism in older adults is common yet understudied, particularly its effects on depression treatment outcomes. We hypothesized that presence of high neuroticism would be associated with lower 12-week remission rates in older depressed sertraline-treated patients. In this longitudinal cohort study, 43 depressed older adults completed the Revised NEO Personality Inventory (NEO PI-R). A study psychiatrist administered the Montgomery Ǻsberg Depression Rating Scale (MADRS), and the Cumulative Illness Rating Scale (CIRS, a measure of medical burden) at baseline, and the MADRS at each clinical visit. All subjects began open-label sertraline treatment and were followed over 12 weeks with clinically indicated flexible dosing and an option to switch antidepressants. We used regression analyses to examine factors related to 12-week remission of depression (MADRS score < 8) and final MADRS score. We found that higher total neuroticism (odds ratio (OR) = 0.963, 95% confidence interval (CI) = 0.928-1.000) and a neuroticism subscale, stress vulnerability (OR = 0.846, 95% CI = 0.728-0.983), were associated with lower likelihood of remission among both the intention-to-treat group and sertraline completers. Findings remained significant after controlling for baseline MADRS and CIRS score. In conclusion, assessment of personality, particularly features of neuroticism, may be important in management of late-life depression. Future studies should determine if depressed patients high in neuroticism may benefit from psychotherapy focusing on emotional regulation and stress management.
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