Evidence map›Paper›PMID 29198102›Full record

ArticleACS infectious diseases2018

Antimicrobial and Antibiofilm Activity of Human Milk Oligosaccharides against Streptococcus agalactiae, Staphylococcus aureus, and Acinetobacter baumannii.

Dorothy L Ackerman, Kelly M Craft, Ryan S Doster, Jörn-Hendrik Weitkamp, David M Aronoff, Jennifer A Gaddy, Steven D Townsend

Open access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
6.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 96 citations in OpenAlex.

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  14. Antimicrobial Properties of Colostrum and Milk.Antibiotics (Basel, Switzerland) · 2024
    Review
  15. Review
  16. Importance of human milk for infants in the clinical setting: Updates and mechanistic links.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2023
    Review
  17. Review
  18. Article
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Dorothy L AckermanDepartment of Chemistry , Vanderbilt University , 7330 Stevenson Center , Nashville , Tennessee 37235 , United States.
Kelly M CraftDepartment of Chemistry , Vanderbilt University , 7330 Stevenson Center , Nashville , Tennessee 37235 , United States.ORCID 0000-0001-9753-2801
Ryan S DosterDepartment of Medicine , Vanderbilt University Medical Center , 1161 21st Avenue South, D-3100 Medical Center North , Nashville , Tennessee 37232 , United States.
Jörn-Hendrik WeitkampDepartment of Medicine , Vanderbilt University Medical Center , 1161 21st Avenue South, D-3100 Medical Center North , Nashville , Tennessee 37232 , United States.
David M AronoffDepartment of Medicine , Vanderbilt University Medical Center , 1161 21st Avenue South, D-3100 Medical Center North , Nashville , Tennessee 37232 , United States.ORCID 0000-0003-4587-6121
Jennifer A GaddyDepartment of Medicine , Vanderbilt University Medical Center , 1161 21st Avenue South, D-3100 Medical Center North , Nashville , Tennessee 37232 , United States.
Steven D TownsendDepartment of Chemistry , Vanderbilt University , 7330 Stevenson Center , Nashville , Tennessee 37235 , United States.ORCID 0000-0001-5362-7235
Vanderbilt University · USVanderbilt University Medical Center · USMonroe Carell Jr. Children's Hospital · USVA Tennessee Valley Healthcare System · US

Funding

Chemistry-Biology Interface Training GrantT32GM065086 · NIGMS · VANDERBILT UNIVERSITY · PI BACHMANN, BRIAN O, SULIKOWSKI, GARY ALLEN · 2002 to 2022
$7.0M
Regulation of Helicobacter pylori pili encoded by the cag pathogenicity islandIK2BX001701 · VA · VETERANS HEALTH ADMINISTRATION · PI GADDY, JENNIFER A · 2013 to 2017
–
BLRD VA IK2 BX001701NIGMS NIH HHS T32 GM065086
6 · The paper itself

Abstract

In a previous study, we reported that human milk oligosaccharides (HMOs) isolated from five donor milk samples possessed antimicrobial and antibiofilm activity against Streptococcus agalactiae, also known as Group B Streptococcus or GBS. Herein, we present a broader evaluation of the antimicrobial and antibiofilm activity by screening HMOs from 14 new donors against three strains of GBS and two of the ESKAPE pathogens of particular interest to child health, Staphylococcus aureus and Acinetobacter baumannii. Growth and biofilm assays showed that HMOs from these new donors possessed antimicrobial and antibiofilm activity against all three strains of GBS, antibiofilm activity against methicillin-resistant S. aureus strain USA300, and antimicrobial activity against A. baumannii strain ATCC 19606.

Indexed as

Acinetobacter baumanniiAnti-Bacterial AgentsBiofilmsBiological ProductsFemaleHumansMicrobial Sensitivity TestsMilk, HumanOligosaccharidesStaphylococcus aureusStreptococcus agalactiaeAnti-Bacterial AgentsBiological ProductsOligosaccharidesA. baumanniiantibiofilmantimicrobialGBSS. agalactiaeS. aureus

Identifiers

PMID29198102
PMCPMC6019282
OpenAlexW2774425402

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.