ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2018
Characteristics, management, and outcome of primary hyperparathyroidism at a single clinical center from 2005 to 2016.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 34 citations in OpenAlex.
- Clinical evolution of primary hyperparathyroidism in China: A 40-year retrospective single-center study.Chinese medical journal · 2026Article
- Surgical training program of parathyroidectomy for residents in a national center: a cohort of 122 cases.Surgery in practice and science · 2026Article
- Age-stratified differences in asymptomatic primary hyperparathyroidism: a single-center cohort study from 2017 to 2024.Gland surgery · 2026Article
- Diagnostic efficacy of ([Ca]×[Cl])/P combined with ALP in the diagnosis and subtype differentiation of primary hyperparathyroidism.Frontiers in endocrinology · 2026Article
- Trends in Clinical Features of Primary Hyperparathyroidism During 2013-2024.International journal of endocrinology · 2026Article
- Primary hyperparathyroidism during pregnancy: ultrasound as an accurate preoperative localization imaging modality.Orphanet journal of rare diseases · 2025Article
- A retrospective study on a nomogram combining clinical and ultrasound parameters for differentiating solitary parathyroid adenoma from carcinoma or atypical tumors.Frontiers in endocrinology · 2025Article
- Diagnostic accuracy of ultrasonography and 99m-Technetium Sestamibi scintigraphy for the preoperative localization of Parathyroid Adenoma keeping histopathological findings as reference standard.Pakistan journal of medical sciences · 2024Article
- Outcome of Primary Hyperparathyroidism: Retrospective Tertiary Center Experience From Basrah, Iraq.Cureus · 2024Article
- Characteristics, management and outcomes of primary hyperparathyroidism from 2009 to 2021: a single centre report from South Africa.BMC endocrine disorders · 2024Article
- A contemporary analysis of the pre- and intraoperative recognition of multigland parathyroid disease.Langenbeck's archives of surgery · 2023Review
- Symptomatic versus asymptomatic primary hyperparathyroidism: A systematic review and meta-analysis.Journal of clinical & translational endocrinology · 2023Article
- Prevalence and associated risk factors of simple renal cysts in primary hyperparathyroidism.Hormones (Athens, Greece) · 2023Article
- Epidemiology, Pathophysiology, and Genetics of Primary Hyperparathyroidism.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Review
- Changes in clinical patterns of Chinese patients with primary hyperparathyroidism in the past 12 years: a single-center experience.Endocrine connections · 2021Article
- Comparative analysis of clinicopathologic features between adenoma and hyperplasia in surgically treated patients for hyperparathyroidism: A retrospective study.Annals of medicine and surgery (2012) · 2021Article
- [Normocalcemic with elevated post-operative parathormone in primary hyperpara-thyroidism: 9 case reports and literature review].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2021Review
- Clinical characteristics of the patients with asymptomatic primary hyperparathyroidism.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021Article
- Progressive rise in the prevalence of asymptomatic primary hyperparathyroidism in India: Data from PHPT registry.Journal of bone and mineral metabolism · 2021Article
- Factors That Affect the Sensitivity of Imaging Modalities in Primary Hyperparathyroidism.International journal of endocrinology · 2021Article
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Abstract
This study presents the clinical and biochemical profiles of patients with PHPT between 2005 and 2016 at our center. Most PHPT patients in China show symptomatic features. The number of symptomatic and asymptomatic patients increased during that time, and the number of individuals with parathyroid carcinoma is now increasing.
introductionOver the last decade, the prevalence of primary hyperparathyroidism (PHPT) has increased sharply, and the number of individuals with parathyroid cancer is still trending upward. Little is known about the clinical outlook of the disease over the last decade in China. The aim of this study was to describe the clinical characteristics of PHPT patients at our center from January 2005 to December 2016.
methodsTwo hundred sixty patients with PHPT visiting Shanghai Jiao Tong University Affiliated Sixth People's Hospital were enrolled retrospectively. The clinical manifestations and biochemical abnormalities of these patients were analyzed.
resultsAmong all patients, 73.1% had symptomatic PHPT, while the number of symptomatic and asymptomatic patients increased 1 to 2.5 times and 1.5 to 3 times, respectively, from 2005 to 2016. Bone pain and single adenoma were the most frequent signs and pathological results. The patients with parathyroid carcinoma over the last 5 years accounted for 90% (9/10) of all parathyroid carcinoma patients from 2005 to 2016, and parathyroid carcinoma patients had higher levels of serum calcium, parathyroid hormone (PTH), and serum creatinine (P < 0.05) than parathyroid hyperplasia and parathyroid adenoma patients.
conclusionsMost patients with PHPT in China still exhibit classic clinical and biochemical features. Both symptomatic and asymptomatic patients have increased over the last 12 years. Although the proportion of parathyroid carcinoma was small, a noticeable upward tendency was observed at our center.
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