ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2018
Apert syndrome: magnetic resonance imaging (MRI) of associated intracranial anomalies.
Review in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Cranial nerves involvement in craniosynostosis: a systematic review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Pooled it
- Gallbladder Hypoplasia With Intestinal Malrotation in a Patient With Apert Syndrome: A Case Report.Case reports in surgery · 2026Article
- From FGFR2 mutations to precision management: a review of prenatal diagnosis and multidisciplinary interventions in apert syndrome.Frontiers in pediatrics · 2025Review
- Apert syndrome in a newborn with premature fusion of skull bones, a rostral nose, and cleft palate: A case report.Clinical case reports · 2024Article
- The interaction between the nervous system and the stomatognathic system: from development to diseases.International journal of oral science · 2023Review
- Common Neuroimaging Findings in Bosch-Boonstra-Schaaf Optic Atrophy Syndrome.AJNR. American journal of neuroradiology · 2023Article
- Multisuture and Syndromic Craniosynostoses: Simplifying the Complex.Journal of pediatric neurosciences · 2022Review
- Visualization of the Cartilage and Bone Elements in the Craniofacial Structures by Alcian Blue and Alizarin Red Staining.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Clinical application of "black bone" imaging in paediatric craniofacial disorders.The British journal of radiology · 2021Review
- Prenatal genetic considerations in congenital ventriculomegaly and hydrocephalus.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Review
- Apert syndrome: Cranial procedures and brain malformations in a series of patients.Surgical neurology international · 2020Article
- Classification of Subtypes of Apert Syndrome, Based on the Type of Vault Suture Synostosis.Plastic and reconstructive surgery. Global open · 2019Article
- Fetal brain MRI in Apert syndrome: early in vivo detection of temporal lobe malformation.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Article
- Primary normocephalic pancraniosynostosis detected incidentally after an accidental head injury: a case report and review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Review
- A child with Apert syndrome and Sturge-Weber syndrome: could fibronectin or the RAS/MAPK signaling pathway be the connection?Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionApert syndrome is one of the most common craniosynostosis syndrome caused by mutations in genes encoding fibroblast growth factor receptor 2 (FGFR2). It is characterized by multisuture craniosynostosis, midfacial hypoplasia, abnormal skull base development and syndactyly of all extremities. Apert syndrome is associated with a wide array of central nervous system (CNS) anomalies, possibly the cause of the common occurrence of mental deficiency in patients with Apert syndrome. These CNS anomalies can be broadly classified into two groups; (1) those that are primary malformations and (2) those that occur secondary to osseous deformity/malformation.
conclusionFamiliarity with CNS anomalies associated with Apert syndrome is important to both clinicians and radiologist as it impacts on management and prognostication. Cognitive development of patients has been linked to associated CNS anomalies, timing of surgery and social aspects. These associated anomalies can be broadly classified into (1) those that are primary malformations and (2) those that occur secondary to osseous deformity/malformation, as illustrated in our review paper.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.