Evidence map›Paper›PMID 29198070›Full record

Trial reportObesity surgery2018

Sugar Detection Threshold After Laparoscopic Sleeve Gastrectomy in Adolescents.

Ghalia N Abdeen, Alexander D Miras, Aayed R Alqhatani, Carel W le Roux

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Obesity surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 4 countries.

Ghalia N AbdeenDivision of Diabetes, Endocrinology and Metabolism, Imperial College, London, UK.
Alexander D MirasDivision of Diabetes, Endocrinology and Metabolism, Imperial College, London, UK.
Aayed R AlqhataniDepartment of Surgery, College of Medicine, King Saud University, Dublin, Ireland. qahtani@yahoo.com.
Carel W le RouxDivision of Diabetes, Endocrinology and Metabolism, Imperial College, London, UK.
Imperial College London · GBKing Saud University · SAUniversity of Gothenburg · SE

Funding

Medical Research Council G0902002
6 · The paper itself

Abstract

introductionObesity in young people is one of the most serious public health problems worldwide. Moreover, the mechanisms preventing obese adolescents from losing and maintaining weight loss have been elusive. Laparoscopic sleeve gastrectomy (LSG) is successful at achieving long-term weight loss in patients across all age groups, including children and adolescents. Anecdotal clinical observation as well as evidence in rodents suggests that LSG induces a shift in preference of sugary foods. However, it is not known whether this shift is due to a change in the threshold for gustatory detection of sucrose, or whether LSG induces behavioral change without affecting the gustatory threshold for sugar.

aimsThe objective of this study was to determine whether adolescents who undergo LSG experience a change in their threshold for detecting sweet taste.

methodsWe studied the sucrose detection threshold of 14 obese adolescents (age 15.3 ± 0.5 years, range 12-18) who underwent LSG 2 weeks before surgery and at 12 and 52 weeks after surgery. Matched non-surgical subjects were tested on two occasions 12 weeks apart to control for potential learning of the test that may have confounded the results. Seven sucrose concentrations were used and were tested in eight blocks with each block consisting of a random seven sucrose and seven water stimuli. The subjects were asked to report whether the sample contained water or not after they tasted 15 ml of the fluid for 10 s.

resultsThe bodyweight of the LSG group decreased from 136.7 ± 5.4 to 109.6 ± 5.1 and 86.5 ± 4.0 kg after 12 and 52 weeks, respectively (p < 0.001). There was no significant difference after surgery in taste detection threshold of patients after LSG (p = 0.60), and no difference was observed comparing the taste detection threshold of the LSG group with the non-surgical controls (p = 0.38).

conclusionLSG did not affect the taste detection threshold for sucrose, suggesting that the shift in preference for sugary foods may be due to factors other than fundamental changes in taste sensitivity.

Indexed as

GastrectomySugarsTaste ThresholdAdolescentCase-Control StudiesChildFemaleHumansLaparoscopyMaleObesity, MorbidPediatric ObesityPostoperative ComplicationsTasteTreatment OutcomeWeight LossSugarsAdolescentsSleeve gastrectomySweets preferenceTaste detection

Identifiers

PMID29198070
OpenAlexW2771223740

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.