ArticleEuropean journal of clinical pharmacology2018
Development and pilot testing of PHARAO-a decision support system for pharmacological risk assessment in the elderly.
Article in European journal of clinical pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk assessment tools for QT prolonging pharmacotherapy in older adults: a systematic review.European journal of clinical pharmacology · 2022Pooled it
- Effectiveness of a Hospital-Based Computerized Decision Support System on Clinician Recommendations and Patient Outcomes: A Randomized Clinical Trial.JAMA network open · 2019Trial
- Coordinating resources for prospective medication risk management of older home care clients in primary care: procedure development and RCT study design for demonstrating its effectiveness.BMC geriatrics · 2018Trial
- Drug-Induced QT Prolongation: Associations Between Risk Classifications in a Swedish Clinical Decision Support System and Clinical Outcomes.Clinical pharmacology and therapeutics · 2026Article
- Prescribed drugs and comorbidities as risk factors for Torsades de Pointes arrhythmia: a Swedish population-based cohort study.European journal of clinical pharmacology · 2026Article
- QT prolongation alerts lead to monitoring but rarely to therapeutic changes: a prospective hospital study.Frontiers in pharmacology · 2026Article
- Exploring the need for a clinical decision support system for deprescribing - A qualitative interview study.Exploratory research in clinical and social pharmacy · 2025Article
- Potential Adverse Drug Events Identified with Decision Support Algorithms from Janusmed Risk Profile-A Retrospective Population-Based Study in a Swedish Region.Pharmacy (Basel, Switzerland) · 2024Article
- Evaluating EHR-Integrated Digital Technologies for Medication-Related Outcomes and Health Equity in Hospitalised Adults: A Scoping Review.Journal of medical systems · 2024Article
- Collaborative medication reviews in community pharmacies-Drug-related problems and the process of communicating them with physicians: A retrospective validation study.Health science reports · 2024Article
- Medicines postpartum in Sweden and coverage in Janusmed Breastfeeding.European journal of clinical pharmacology · 2023Article
- The Relationship of Kidney Function, Cardiovascular Morbidity, and All-Cause Mortality: a Prospective Primary Care Cohort Study.Journal of general internal medicine · 2023Article
- Pharmacological Risk Assessment Among Older Patients with Polypharmacy Using the Clinical Decision Support System Janusmed Risk Profile: A Cross-Sectional Register Study.Drugs & aging · 2023Article
- A Personalized Ontology-Based Decision Support System for Complex Chronic Patients: Retrospective Observational Study.JMIR formative research · 2022Article
- Drug interaction alerts in older primary care patients, and related medically justified actions.European journal of clinical pharmacology · 2022Article
- Health information technology to improve care for people with multiple chronic conditions.Health services research · 2021Review
- Patients' Use and Perceptions of a Drug-Drug Interaction Database: A Survey of Janusmed Interactions.Pharmacy (Basel, Switzerland) · 2021Article
- Kidney function and nephrotoxic drug use among older home-dwelling persons with or without diabetes in Finland.BMC nephrology · 2020Article
- Drug information centre queries and responses about drug interactions over 10 years-A descriptive analysis.Basic & clinical pharmacology & toxicology · 2020Article
- Clinical relevance of alerts from a decision support system, PHARAO, for drug safety assessment in the older adults.BMC geriatrics · 2019Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aims of this study are to describe the development of PHARAO (Pharmacological Risk Assessment Online), a decision support system providing a risk profile for adverse events, associated with combined effects of multiple medicines, and to present data from a pilot study, testing the use, functionality, and acceptance of the PHARAO system in a clinical setting.
methodsAbout 1400 substances were scored in relation to their risk to cause any of nine common and/or serious adverse effects. Algorithms for each adverse effect score were developed to create individual risk profiles from the patient's list of medication. The system was tested and integrated to the electronic medical record, during a 4-month period in two geriatric wards and three primary healthcare centers, and a questionnaire was answered by the users before and after the test period.
resultsA total of 732 substances were tagged with one or more of the nine risks, most commonly with the risk of sedation or seizures. During the pilot, the system was used 933 times in 871 patients. The most common signals generated by PHARAO in these patients were related to the risks of constipation, sedation, and bleeding. A majority of responders considered PHARAO easy to use and that it gives useful support in performing medication reviews.
conclusionsThe PHARAO decision support system, designed as a complement to a database on drug-drug interactions used nationally, worked as intended and was appreciated by the users during a 4-month test period. Integration aspects need to be improved to minimize unnecessary signaling.
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