Evidence map›Paper›PMID 29197967›Full record

ArticleJournal of cancer research and clinical oncology2018

Effects of nutraceuticals on anaplastic thyroid cancer cells.

Lorenzo Allegri, Francesca Rosignolo, Catia Mio, Sebastiano Filetti, Federica Baldan, Giuseppe Damante

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 46 citations in OpenAlex.

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  17. Sesquiterpene Lactones fromMolecules (Basel, Switzerland) · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lorenzo AllegriDepartment of Medical Area, University of Udine, 33100, Udine, Italy.
Francesca RosignoloDepartment of Internal Medicine and Medical Specialties, "Sapienza" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
Catia MioDepartment of Medical Area, University of Udine, 33100, Udine, Italy.
Sebastiano FilettiDepartment of Internal Medicine and Medical Specialties, "Sapienza" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
Federica BaldanDepartment of Internal Medicine and Medical Specialties, "Sapienza" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy. federica.baldan12@gmail.com.ORCID http://orcid.org/0000-0003-1164-1316
Giuseppe DamanteDepartment of Medical Area, University of Udine, 33100, Udine, Italy.
Policlinico Umberto I · ITUniversity of Udine · IT

Funding

Associazione Italiana per la Ricerca sul Cancro 19481Ministero degli Affari Esteri e della Cooperazione Internazionale PGR02954Ministero dell'Istruzione, dell'Università e della Ricerca 2015HPMLFY-011
6 · The paper itself

Abstract

purposeThe anaplastic thyroid carcinoma (ATC) is the most aggressive thyroid cancer with a high mortality rate. Since nutraceuticals may exert beneficial effects on tumor biology, here, effects of four of these compounds [resveratrol, genistein, curcumin and epigallocatechin-3-gallate (EGCG)] on ATC cell lines were investigated.

methodsTwo ATC-derived cell lines were used: SW1736 and 8505C. Cell viability and in vitro aggressiveness was tested by MTT and soft agar assays. Apoptosis was investigated by Western Blot, using an anti-cleaved-PARP antibody. mRNA and miRNA levels were quantified by real-time PCR.

resultsAll tested nutraceuticals caused in both cell lines decrease of cell viability and increase of apoptosis. In contrast, only curcumin reduced in vitro aggressiveness in both SW1736 and 8505C cell lines, while genistein and EGCG determined a reduction of colony formation only in 8505C cells. Effects on genes related to the thyroid-differentiated phenotype were also tested: resveratrol and genistein administration determined the increment of almost all tested mRNAs in both cell lines. Instead curcumin and EGCG treatments had opposite effects in the two cell lines, causing the increment of almost all the mRNAs in 8505C cells and their reduction in SW1736. Finally, effects of nutraceuticals on levels of several miRNAs, known as important in thyroid cancer progression (hsa-miR-221, hsa-miR-222, hsa-miR-21, hsa-miR-146b, hsa-miR-204), were tested. Curcumin induced a strong and significant reduction of all miR analyzed, except for has-miR-204, in both cell lines.

conclusionsAltogether, our results clearly indicate the anti-cancer proprieties of curcumin, suggesting the promising use of this nutraceutical in ATC treatment. Resveratrol, genistein and EGCG have heterogeneous effects on molecular features of ATC cells.

Indexed as

Dietary SupplementsAntineoplastic Agents, PhytogenicApoptosisCatechinCell DifferentiationCell Growth ProcessesCell Line, TumorCurcuminGenisteinHumansMicroRNAsResveratrolStilbenesThyroid Carcinoma, AnaplasticThyroid NeoplasmsAntineoplastic Agents, PhytogenicCatechinCurcuminepigallocatechin gallateGenisteinMicroRNAsResveratrolStilbenesCurcuminEGCG, ATCGenisteinNutraceuticalsResveratrol

Identifiers

PMID29197967
PMCPMC11813496
OpenAlexW2774612021

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.