Evidence map›Paper›PMID 29197828›Full record

ArticleJournal of the American Heart Association2017

Matrine-Type Alkaloids Inhibit Advanced Glycation End Products Induced Reactive Oxygen Species-Mediated Apoptosis of Aortic Endothelial Cells In Vivo and In Vitro by Targeting MKK3 and p38MAPK Signaling.

Zhongwei Liu, Ying Lv, Yong Zhang, Fuqiang Liu, Ling Zhu, Shuo Pan, Chuan Qiu, Yan Guo, Tielin Yang, Junkui Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 40 citations in OpenAlex.

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  20. Resveratrol Attenuates Cognitive Deficits of Traumatic Brain Injury by Activating p38 Signaling in the Brain.Medical science monitor : international medical journal of experimental and clinical research · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Zhongwei LiuDepartment of Cardiology, Shaanxi Provincial People's Hospital, Xi'an Jiaotong University, Xi'an, China.
Ying LvDepartment of Cardiology, Shaanxi Provincial People's Hospital, Xi'an Jiaotong University, Xi'an, China.
Yong ZhangDepartment of Cardiology, Shaanxi Provincial People's Hospital, Xi'an Jiaotong University, Xi'an, China.
Fuqiang LiuDepartment of Cardiology, Shaanxi Provincial People's Hospital, Xi'an Jiaotong University, Xi'an, China.
Ling ZhuDepartment of Cardiology, Shaanxi Provincial People's Hospital, Xi'an Jiaotong University, Xi'an, China.
Shuo PanDepartment of Cardiology, Shaanxi Provincial People's Hospital, Xi'an Jiaotong University, Xi'an, China.
Chuan QiuDepartment of Biostatistics & Bioinformatics, School of Public Health & Tropical Medicine, Tulane University, New Orleans, LA.
Yan GuoInstitute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China.
Tielin YangInstitute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China.
Junkui WangDepartment of Cardiology, Shaanxi Provincial People's Hospital, Xi'an Jiaotong University, Xi'an, China junkuiwang@yeah.net.
Shaanxi Provincial People's Hospital · CNXi'an Jiaotong University · CNTulane University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe matrine-type alkaloids are bioactive components extracted from METHODS AND

resultsRats aorta and cultured rat aortic endothelial cells were exposed to advanced glycation end products. Matrine-type alkaloids, p38 mitogen-activated protein kinase (MAPK) inhibitor, and small interference RNAs against p38 MAPK kinases MAPK kinase kinase (MKK)3 and MKK6 were administrated. Intracellular reactive oxygen species production, cell apoptosis, phosphorylation of MKKs/p38 MAPK, and expression levels of heme oxygenase/NADPH quinone oxidoreductase were assessed. The nuclear factor erythroid 2-related factor 2 nuclear translocation and the binding activity of nuclear factor erythroid 2-related factor 2 with antioxidant response element were also evaluated. Matrine-type alkaloids suppressed intracellular reactive oxygen species production and inhibited endothelial cell apoptosis in vivo

conclusionsMatrine-type alkaloids exert endothelial protective effects against advanced glycation end products induced reactive oxygen species-mediated apoptosis by targeting MKK3/6 and enhancing their phosphorylation.

Indexed as

AlkaloidsAnimalsAntioxidantsApoptosisCells, CulturedCytoprotectionDose-Response Relationship, DrugEndothelial CellsGlycation End Products, AdvancedMaleMAP Kinase Kinase 3MAP Kinase Kinase 6MatrinesNF-E2-Related Factor 2Oxidative Stressp38 Mitogen-Activated Protein Kinasesadvanced glycation end products-bovine serum albuminAlkaloidsAntioxidantsGlycation End Products, AdvancedMap2k3 protein, ratMAP Kinase Kinase 3MAP Kinase Kinase 6MatrinesNfe2l2 protein, ratNF-E2-Related Factor 2oxymatrinep38 Mitogen-Activated Protein KinasesQuinolizinesReactive Oxygen SpeciesSerum Albumin, Bovinesophocarpineapoptosisdiabetes mellitusendothelial cellmatrine‐type alkaloidsreactive oxygen species

Identifiers

PMID29197828
PMCPMC5779049
OpenAlexW2773922081

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.