ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2018
Abnormal cortical neural synchrony during working memory in schizophrenia.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Altered thalamo-prefrontal synchrony dynamics during spatial working memory task performance in a SETD1A loss-of-function mouse model of schizophrenia predisposition.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Simultaneous EEG-fMRI Reveals a Visual Working Memory Encoding Network Related to Theta Oscillatory Activity in Healthy Subjects.Human brain mapping · 2025Article
- Dysfunctional Alpha Modulation as a Mechanism of Working Memory Impairment in Serious Mental Illness.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Sulcal variability in anterior lateral prefrontal cortex contributes to variability in reasoning performance among young adults.Brain structure & function · 2024Article
- Transcranial alternating current stimulation ameliorates emotional attention through neural oscillations modulation.Cognitive neurodynamics · 2023Article
- Gamma-band entrainment abnormalities in schizophrenia: Modality-specific or cortex-wide impairment?Journal of psychopathology and clinical science · 2022Article
- Metabotropic glutamate receptor 3 as a potential therapeutic target for psychiatric and neurological disorders.Pharmacology, biochemistry, and behavior · 2022Review
- Multiscale Weighted Permutation Entropy Analysis of Schizophrenia Magnetoencephalograms.Entropy (Basel, Switzerland) · 2022Article
- Disparate insults relevant to schizophrenia converge on impaired spike synchrony and weaker synaptic interactions in prefrontal local circuits.Current biology : CB · 2022Article
- Enhanced Performance by Interpretable Low-Frequency Electroencephalogram Oscillations in the Machine Learning-Based Diagnosis of Post-traumatic Stress Disorder.Frontiers in neuroinformatics · 2022Article
- Neural basis of the visual working memory deficit in schizophrenia: Merging evidence from fMRI and EEG.Schizophrenia research · 2021Article
- CPNE3 moderates the association between anxiety and working memory.Scientific reports · 2021Article
- Inhibition of 14-3-3 Proteins Alters Neural Oscillations in Mice.Frontiers in neural circuits · 2021Article
- The Modulation of Working-Memory Performance Using Gamma-Electroacupuncture and Theta-Electroacupuncture in Healthy Adults.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Dependence of Working Memory on Coordinated Activity Across Brain Areas.Frontiers in systems neuroscience · 2021Review
- Translation-Focused Approaches to GPCR Drug Discovery for Cognitive Impairments Associated with Schizophrenia.ACS pharmacology & translational science · 2020Review
- Disruption of gamma-delta relationship related to working memory deficits in first-episode psychosis.Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
- Decoding Three Different Preference Levels of Consumers Using Convolutional Neural Network: A Functional Near-Infrared Spectroscopy Study.Frontiers in human neuroscience · 2020Article
- Dysfunctional Neural Processes Underlying Context Processing Deficits in Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Neurophysiological correlates of cognitive control and approach motivation abnormalities in adolescent bipolar disorders.Cognitive, affective & behavioral neuroscience · 2019Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveTo better understand the origins of working memory (WM) impairment in schizophrenia we investigated cortical oscillatory activity in people with schizophrenia (PSZ) while they performed a WM task requiring encoding, maintenance, and retrieval/manipulation processes of spatial information.
methodsWe examined time-frequency synchronous energy of cortical source signals that were derived from magnetoencephalography (MEG) localized to cortical regions using WM-related hemodynamic responses and individualized structural head-models.
resultsCompared to thirteen healthy controls (HC), twelve PSZ showed performance deficits regardless of WM-load or duration. During encoding, PSZ had early theta and delta event-related synchrony (ERS) deficits in prefrontal and visual cortices which worsened with greater memory load and predicted WM performance. During prolonged maintenance of material, PSZ showed deficient beta event-related desynchrony (ERD) in dorsolateral prefrontal, posterior parietal, and visual cortices. In retrieval, PSZ showed reduced delta/theta ERS in the anterior prefrontal and ventral visual cortices and diminished gamma ERS in the premotor and posterior parietal cortices.
conclusionsAlthough beta/gamma cortical neural oscillatory deficits for maintenance/retrieval are evident during WM, the abnormal prefrontal theta-frequency ERS for encoding is most predictive of poor WM in schizophrenia. SIGNIFICANCE: Time-frequency-spatial analysis identified process- and frequency-specific neural synchrony abnormalities underlying WM deficits in schizophrenia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.