Evidence map›Paper›PMID 29197729›Full record

ArticleEuropean journal of medicinal chemistry2018

Targeting tubulin polymerization by novel 7-aryl-pyrroloquinolinones: Synthesis, biological activity and SARs.

Roberta Bortolozzi, Elena Mattiuzzo, Matteo Dal Pra, Mattia Sturlese, Stefano Moro, Ernest Hamel, Davide Carta, Giampietro Viola, Maria Grazia Ferlin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medicinal chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Bioactive pyrrole-based compounds with target selectivity.European journal of medicinal chemistry · 2020
    Review
  3. Synthesis of Pyrrolo[3,4-Molecules (Basel, Switzerland) · 2019
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Roberta BortolozziDepartment of Woman's and Child's Health, University of Padova, Laboratory of Oncohematology, 35128 Padova, Italy.
Elena MattiuzzoDepartment of Woman's and Child's Health, University of Padova, Laboratory of Oncohematology, 35128 Padova, Italy.
Matteo Dal PraDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.
Mattia SturleseDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.
Stefano MoroDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.
Ernest HamelScreening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, Frederick National Laboratory for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
Davide CartaDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.
Giampietro ViolaDepartment of Woman's and Child's Health, University of Padova, Laboratory of Oncohematology, 35128 Padova, Italy.
Maria Grazia FerlinDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy. Electronic address: mariagrazia.ferlin@unipd.it.
University of Padua · ITFrederick National Laboratory for Cancer Research · US

Funding

Intramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

Earlier studies had confirmed that the 7-phenylpyrroloquinolinone (7-PPyQ) nucleus was an important scaffold for new chemotherapeutic drugs targeting microtubules. For wide-ranging SARs, a series of derivatives were synthesized through a robust procedure. For comparison with the reference 3-ethyl-7-PPyQ 31, the angular geometry and substituents at the 3 and 7 positions were varied to explore interactions inside the colchicine site of tubulin. Of the new compounds synthesized, potent cytotoxicity (low and sub-nanomolar GI

Indexed as

Antineoplastic AgentsApoptosisCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHeLa CellsHumansLeukocytes, MononuclearMembrane Potential, MitochondrialMolecular StructurePolymerizationQuinolonesStructure-Activity RelationshipTubulinAntineoplastic AgentsQuinolonesTubulinApoptosisMicrotubulesMolecular dockingPhenylpyrroloquinolinoneStructure-activity relationshipsTubulin

Identifiers

PMID29197729
PMCPMC5798451
OpenAlexW2770472795

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.