Evidence map›Paper›PMID 29197551›Full record

ArticleToxicology2018

Allelic variants of the aryl hydrocarbon receptor differentially influence UVB-mediated skin inflammatory responses in SKH1 mice.

Kayla J Smith, Iain A Murray, Jacob A Boyer, Gary H Perdew

Abstract read
In one paragraph

Article in Toxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kayla J SmithThe Graduate Program in Biochemistry, Microbiology, and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, United States.
Iain A MurrayDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University,University Park, PA 16802, United States; Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University,University Park, PA 16802, United States.
Jacob A BoyerCenter for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University,University Park, PA 16802, United States.
Gary H PerdewDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University,University Park, PA 16802, United States; Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University,University Park, PA 16802, United States. Electronic address: ghp2@psu.edu.
Pennsylvania State University · US

Funding

Activation of the Ah receptor and epithelial integrityR35ES028244 · NIEHS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PERDEW, GARY H. · 2017 to 2024
$6.2M
REGULATION OF THE AH RECEPTORR01ES004869 · NIEHS · PURDUE UNIVERSITY WEST LAFAYETTE · PI PERDEW, GARY H. · 1994 to 2017
$5.3M
Selective Ah Receptor Ligands Repress Acute-Phase ResponseR01ES019964 · NIEHS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PERDEW, GARY H. · 2012 to 2016
$2.0M
Training in Animal Models of InflammationT32AI074551 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI GIBLIN, PAMELA A · 2011 to 2015
$940k
NIAID NIH HHS T32 AI074551NIEHS NIH HHS R01 ES004869NIEHS NIH HHS R01 ES019964NIEHS NIH HHS R35 ES028244
6 · The paper itself

Abstract

The mouse strain SKH1 is widely used in skin research due to its hairless phenotype and intact immune system. Due to the complex nature of aryl hydrocarbon receptor (AHR) function in the skin, the development of additional in vivo models is necessary to study its role in cutaneous homeostasis and pathology. Variants of the Ah allele, exist among different mouse strains. The Ah

Indexed as

AllelesAmino Acid SequenceAnimalsCytochrome P-450 CYP1A1DermatitisGene ExpressionGenetic VariationLiverMaleMiceMice, Inbred C57BLMice, TransgenicReceptors, Aryl HydrocarbonSkinUltraviolet RaysCytochrome P-450 CYP1A1Receptors, Aryl HydrocarbonAHRAh receptorSKH1UVB

Identifiers

PMID29197551
PMCPMC5756104
OpenAlexW2772196805

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.