Evidence map›Paper›PMID 29197478›Full record

ArticleMechanisms of ageing and development2018

Cardiomyocyte ionic currents in intact young and aged murine Pgc-1β

Haseeb Valli, Shiraz Ahmad, Anita Y Jiang, Robert Smyth, Kamalan Jeevaratnam, Hugh R Matthews, Christopher L-H Huang

Open access · hybridAbstract read
In one paragraph

Article in Mechanisms of ageing and development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Feedback contributions to excitation-contraction coupling in native functioning striated muscle.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  6. Cardiomyocyte electrophysiology and its modulation: current views and future prospects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Haseeb ValliPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, United Kingdom.
Shiraz AhmadPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, United Kingdom.
Anita Y JiangPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, United Kingdom.
Robert SmythPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, United Kingdom.
Kamalan JeevaratnamPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, United Kingdom; Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7AL, Surrey, United Kingdom; PU-RCSI School of Medicine, Perdana University, 43400 Serdang, Selangor Darul Ehsan, Malaysia.
Hugh R MatthewsPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, United Kingdom.
Christopher L-H HuangPhysiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, United Kingdom; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, United Kingdom. Electronic address: clh11@cam.ac.uk.
University of Cambridge · GBUniversity of Surrey · GB

Funding

British Heart Foundation PG/14/79/31102British Heart Foundation PG/15/12/31280Medical Research Council MR/M001288/1Wellcome TrustWellcome Trust 105727/Z/14/Z
6 · The paper itself

Abstract

introductionRecent studies reported that energetically deficient murine Pgc-1β MATERIALS AND

methodsWe tested a hypothesis implicating Na RESULTS AND DISCUSSION: Depolarising steps activated typical voltage-dependent activating and inactivating inward (Na

Indexed as

Action PotentialsAgingAnimalsArrhythmias, CardiacHeart AtriaIon TransportMiceMice, KnockoutMyocytes, CardiacPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPotassiumSodiumPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPotassiumPpargc1a protein, mouseSodiumAge-dependent arrhythmiaEnergetic deficiencyK(+) currentsNa(+) currentsPgc-1β(−/−)

Identifiers

PMID29197478
PMCPMC5846848
OpenAlexW2775423772

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.