Evidence map›Paper›PMID 29197393›Full record

SynthesisLipids in health and disease2017

Association of serum ferritin with non-alcoholic fatty liver disease: a meta-analysis.

Shui-Xian Du, Lin-Lin Lu, Ning Geng, David W Victor, Li-Zhen Chen, Cong Wang, Hai-Yan Yue, Yong-Ning Xin, Shi-Ying Xuan, Wen-Wen Jin

Open access · goldAbstract readMeta-Analysis
In one paragraph

Synthesis in Lipids in health and disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 5 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 5 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Serum Ferritin and Non-alcoholic Fatty Liver Disease: A Meta-analysis and Systematic Review.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023
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  15. Iron as a therapeutic target in chronic liver disease.World journal of gastroenterology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Shui-Xian DuMedical College of Qingdao University, Qingdao, 266071, China.
Lin-Lin LuDigestive Disease Key Laboratory of Qingdao, Qingdao, 266071, China.
Ning GengDepartment of Gastroenterology, Qingdao Municipal Hospital, 1 Jiaozhou Road, Qingdao, Shandong Province, 266011, China.
David W VictorHepatology & Transplant Medicine, Department of Medicine, Houston Methodist Hospital, Houston, USA.
Li-Zhen ChenDepartment of Gastroenterology, Qingdao Municipal Hospital, 1 Jiaozhou Road, Qingdao, Shandong Province, 266011, China.
Cong WangDepartment of Gastroenterology, Qingdao Municipal Hospital, 1 Jiaozhou Road, Qingdao, Shandong Province, 266011, China.
Hai-Yan YueDepartment of Gastroenterology, Qingdao Municipal Hospital, 1 Jiaozhou Road, Qingdao, Shandong Province, 266011, China.
Yong-Ning XinMedical College of Qingdao University, Qingdao, 266071, China. xinyongning1@163.com.
Shi-Ying XuanMedical College of Qingdao University, Qingdao, 266071, China. xuansydxy1@163.com.
Wen-Wen JinDepartment of Gastroenterology, Qingdao Municipal Hospital, 1 Jiaozhou Road, Qingdao, Shandong Province, 266011, China.
Qingdao Municipal Hospital · CNQingdao University · CNMethodist Hospital · USOcean University of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA growing number of studies reported the connection between the level of serum ferritin (SFL) and non-alcoholic fatty liver disease (NAFLD). However, such connection was still disputable. The aim of our meta-analysis was to estimate SFL between the groups as below: patients with NAFLD against control group; non-alcoholic steatohepatitis (NASH) patients against control group; non-alcoholic fatty liver (NAFL) patients against a control group and NASH patients vs NAFL patients.

methodsWe screened the studies in PubMed, EMBASE, the Cochrane Database and the Cochrane Central register controlled trials from the beginning to July 10, 2016 to find the studies indicated the connection between SFL and NAFLD (NAFL and/or NASH). Fourteen published studies which evaluate the SFL in NAFLD patients were selected.

resultsHigher SFL was noticed in NAFLD patients against control group (standardized mean difference [SMD] 1.01; 95% CI 0.89, 1.13), NASH patients against control group (SMD 1.21; 95% CI 1.00, 1.42), NAFL patients against control group (SMD 0.51; 95% CI 0.24, 0.79) and NASH patients against NAFL patients (SMD 0.63; 95% CI 0.52, 0.75). These results remained unaltered actually after the elimination of studies which were focused on paediatric or adolescent populations. Higher SFL was presented in NAFLD patients against the control group (SMD 1.08; 95% CI 0.95, 1.20) in adults and NASH patients against NAFL patients in adults (SMD 0.74; 95% CI 0.62, 0.87). The connection between SFL and NASH against NAFL group in paediatric or adolescent populations was observed inconsistently (SMD 0.10; 95% CI -0.18, 0.38).

conclusionsThe level of SFL was elevated in patients with NAFLD (NAFL and/or NASH) compared with the controls. Compared with NAFL, The level of SFL was increased in NASH. The result remained unaltered actually after the elimination of studies focused on paediatric or adolescent populations.

Indexed as

BiomarkersCase-Control StudiesFerritinsHumansNon-alcoholic Fatty Liver DiseaseSeverity of Illness IndexBiomarkersFerritinsMeta-analysisNon-alcoholic fatty liver disease (NAFLD)Non-alcoholic fatty liver (NAFL)Non-alcoholic steatohepatitis (NASH)Serum ferritin (SFL)

Identifiers

PMID29197393
PMCPMC5712169
OpenAlexW2772135479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.