Evidence map›Paper›PMID 29197343›Full record

ArticleBMC microbiology2017

Expression and evolutionary patterns of mycobacteriophage D29 and its temperate close relatives.

Rebekah M Dedrick, Travis N Mavrich, Wei L Ng, Graham F Hatfull

Open access · goldAbstract readComparative Study
In one paragraph

Article in BMC microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. The development and use of ActiphageMicrobial biotechnology · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rebekah M DedrickDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
Travis N MavrichDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
Wei L NgDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
Graham F HatfullDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, 15260, USA. gfh@pitt.edu.ORCID http://orcid.org/0000-0002-6705-6821
University of Pittsburgh · US

Funding

PREDOCTORAL TRAINING PROGRAM IN MICROBIAL PATHOGENESIST32AI007640 · NIAID · YALE UNIVERSITY · PI GOODMAN, ANDREW L · 2000 to 2022
$4.3M
Dynamics of viral host range evolutionR01GM116884 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HATFULL, GRAHAM F. · 2015 to 2019
$2.0M
Howard Hughes Medical Institute 54308198National Science Foundation 1247842NIAID NIH HHS T32 AI007640NIGMS NIH HHS R01 GM116884NIH HHS GM116884
6 · The paper itself

Abstract

backgroundMycobacteriophages are viruses that infect Mycobacterium hosts. A large collection of phages known to infect the same bacterial host strain - Mycobacterium smegmatis mc

resultsHere we describe three newly-isolated temperate phages - Kerberos, Pomar16 and StarStuff - that are related to D29, and are predicted to be very close relatives of its putative temperate parent, revealing the repressor and additional genes that are lost in D29. Transcriptional profiles show the patterns of both lysogenic and lytic gene expression and identify highly-expressed, abundant, stable, small non-coding transcripts made from the P

conclusionsComparative genomics of phages D29, Kerberos, Pomar16 and StarStuff provide insights into bacteriophage evolution, and comparative transcriptomics identifies the pattern of lysogenic and lytic expression with unusual features including highly expressed, small, non-coding RNAs.

Indexed as

Evolution, MolecularGene Expression Regulation, ViralBase SequenceDNA, ViralGene Expression ProfilingGenome, ViralLysogenyMutationMycobacteriophagesMycobacterium smegmatisRNA, UntranslatedRNA, ViralSequence AlignmentSequence Analysis, RNAViral InterferenceDNA, ViralRNA, UntranslatedRNA, ViralBacteriophage evolutionRNAseqsRNA

Identifiers

PMID29197343
PMCPMC5712189
OpenAlexW2773114814

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.