Evidence map›Paper›PMID 29197152›Full record

ArticleInfluenza and other respiratory viruses2018

The national burden of influenza-associated severe acute respiratory illness hospitalization in Rwanda, 2012-2014.

José Nyamusore, Joseph Rukelibuga, Mwumvaneza Mutagoma, Andrew Muhire, Alice Kabanda, Thelma Williams, Angela Mutoni, Julius Kamwesiga, Thierry Nyatanyi, Jared Omolo and 8 more

Abstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

José NyamusoreEpidemic Surveillance and Response Division, Rwanda Biomedical Center, Ministry of Health, Kigali, Rwanda.
Joseph RukelibugaInfluenza Program, Centers for Disease Control and Prevention, Kigali, Rwanda.
Mwumvaneza MutagomaEpidemic Surveillance and Response Division, Rwanda Biomedical Center, Ministry of Health, Kigali, Rwanda.
Andrew MuhireHealth Management Information System Division, Ministry of Health, Kigali, Rwanda.
Alice KabandaNational Reference Laboratory, Rwanda Biomedical Center, Ministry of Health, Kigali, Rwanda.
Thelma WilliamsInfluenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Angela MutoniEpidemic Surveillance and Response Division, Rwanda Biomedical Center, Ministry of Health, Kigali, Rwanda.
Julius KamwesigaEpidemic Surveillance and Response Division, Rwanda Biomedical Center, Ministry of Health, Kigali, Rwanda.
Thierry NyatanyiEpidemic Surveillance and Response Division, Rwanda Biomedical Center, Ministry of Health, Kigali, Rwanda.
Jared OmoloInfluenza Program, Centers for Disease Control and Prevention, Kigali, Rwanda.
Adeline KabejaEpidemic Surveillance and Response Division, Rwanda Biomedical Center, Ministry of Health, Kigali, Rwanda.
Jean Baptiste KoamaInfluenza Program, Centers for Disease Control and Prevention, Kigali, Rwanda.
Agrippine MukarurangwaNational Reference Laboratory, Rwanda Biomedical Center, Ministry of Health, Kigali, Rwanda.
Jeanne d'Arc UmuringaNational Reference Laboratory, Rwanda Biomedical Center, Ministry of Health, Kigali, Rwanda.
Carolina GranadosInfluenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Michel GasanaInstitute of HIV/AIDS, Disease Prevention and Control, Rwanda Biomedical Center, Ministry of Health, Kigali, Rwanda.
Ann MoenInfluenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Stefano TempiaInfluenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0003-4395-347X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEstimates of influenza-associated hospitalization are severely limited in low- and middle-income countries, especially in Africa.

objectivesTo estimate the national number of influenza-associated severe acute respiratory illness (SARI) hospitalization in Rwanda.

methodsWe multiplied the influenza virus detection rate from influenza surveillance conducted at 6 sentinel hospitals by the national number of respiratory hospitalization obtained from passive surveillance after adjusting for underreporting and reclassification of any respiratory hospitalizations as SARI during 2012-2014. The population at risk was obtained from projections of the 2012 census. Bootstrapping was used for the calculation of confidence intervals (CI) to account for the uncertainty associated with all levels of adjustment. Rates were expressed per 100 000 population. A sensitivity analysis using a different estimation approach was also conducted.

resultsSARI cases accounted for 70.6% (9759/13 813) of respiratory admissions at selected hospitals: 77.2% (6783/8786) and 59.2% (2976/5028) among individuals aged <5 and ≥5 years, respectively. Overall, among SARI cases tested, the influenza virus detection rate was 6.3% (190/3022): 5.7% (127/2220) and 7.8% (63/802) among individuals aged <5 and ≥5 years, respectively. The estimated mean annual national number of influenza-associated SARI hospitalizations was 3663 (95% CI: 2930-4395-rate: 34.7; 95% CI: 25.4-47.7): 2637 (95% CI: 2110-3164-rate: 168.7; 95% CI: 135.0-202.4) among children aged <5 years and 1026 (95% CI: 821-1231-rate: 11.3; 95% CI: 9.0-13.6) among individuals aged ≥5 years. The estimates obtained from both approaches were not statistically different (overlapping CIs).

conclusionsThe burden of influenza-associated SARI hospitalizations was substantial and was highest among children aged <5 years.

Indexed as

HospitalizationAdolescentAdultAgedChildChild, PreschoolHumansInfantInfluenza, HumanInfluenza VaccinesMiddle AgedPandemicsRetrospective StudiesRisk FactorsRwandaSentinel SurveillanceInfluenza VaccinesburdenhospitalizationinfluenzaRwandasevere acute respiratory illness

Identifiers

PMID29197152
PMCPMC5818355

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.