ArticleAlcoholism, clinical and experimental research2018
Effect of Hazardous Alcohol Use During Pregnancy on Growth Outcomes at Birth: Findings from a South African Cohort Study.
Article in Alcoholism, clinical and experimental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Magnitude and risk factors of khat, alcohol and cigarettes use among pregnant women in Africa: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2024Pooled it
- Alcohol consumption and its associated factors among pregnant women in Sub-Saharan Africa: a systematic review and meta-analysis' as given in the submission system.Substance abuse treatment, prevention, and policy · 2020Pooled it
- Participant experiences with a text message and contingency management intervention for alcohol use during pregnancy and lactation in Cape Town, South Africa.Addiction science & clinical practice · 2025Trial
- Prenatal alcohol use effects on birth, development, and educational outcomes in the Aboriginal and non-Aboriginal populations in the Northern Territory of Australia: a study protocol.BMC pregnancy and childbirth · 2025Article
- Associations of maternal alcohol and non-prescribed substance use with early child growth.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2025Article
- Exposure to Violence and Mental Health Outcomes Among Pre-schoolers in a South African Birth Cohort.Research on child and adolescent psychopathology · 2024Article
- Effect of docosahexaenoic acid and olive oil supplementation on pup weight in alcohol-exposed pregnant rats.Frontiers in pediatrics · 2024Article
- Editorial: Maternal substance and alcohol use and contextual issues.Frontiers in psychiatry · 2024Article
- Perceptions of perinatal alcohol use and treatment needs in Cape Town, South Africa: a qualitative study.Frontiers in psychiatry · 2024Article
- Associations between prenatal alcohol and tobacco exposure on Doppler flow velocity waveforms in pregnancy: a South African study.BMC pregnancy and childbirth · 2023Article
- Pathways to adverse pregnancy outcomes: exploring the mediating role of intimate partner violence and depression: results from a South African rape cohort study.Archives of women's mental health · 2023Article
- Impact of ambient air pollution exposure during pregnancy on adverse birth outcomes: generalized structural equation modeling approach.BMC public health · 2023Article
- Reducing the risk of prenatal alcohol exposure and FASD through social services: promising results from the FAR SEAS pilot project.Frontiers in psychiatry · 2023Article
- Community-based counselling programme for pregnant women with alcohol problems in Cape Town, South Africa: a qualitative study of the views of pregnant women and healthcare professionals.Frontiers in psychiatry · 2023Article
- DNA methylation as a potential mediator of the association between prenatal tobacco and alcohol exposure and child neurodevelopment in a South African birth cohort.Translational psychiatry · 2022Article
- Article
- Intimate partner violence and growth outcomes through infancy: A longitudinal investigation of multiple mediators in a South African birth cohort.Maternal & child nutrition · 2022Article
- Article
- A scoping review of the determinants of foetal alcohol spectrum disorder in South Africa: an intersectional perspective.Health policy and planning · 2021Article
- Maternal psychosocial risk factors and child gestational epigenetic age in a South African birth cohort study.Translational psychiatry · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCohort studies have noted associations between hazardous alcohol use during pregnancy and infant growth outcomes, but many have not controlled for potential psychosocial confounders. To assess the unique contribution of hazardous alcohol use, we examined its effect on infant growth outcomes while controlling for maternal psychosocial stressors and hazardous tobacco and drug use in a cohort of 986 pregnant South African women enrolled into the Drakenstein Child Health Study between 2012 and 2015.
methodsData on psychosocial stressors and maternal risk behaviors were collected between 28 and 32 weeks of gestation. Participants were categorized as hazardous alcohol users if they obtained moderate or high scores (>10) on the Alcohol, Smoking and Substance Involvement Screening Test at this assessment or retrospectively reported drinking at least 2 drinks weekly during any trimester of pregnancy. Infant growth outcomes were recorded at delivery. Multivariable regression models examined correlates of hazardous alcohol use and associations between hazardous alcohol use and birth outcomes.
resultsOverall, 13% of mothers reported hazardous alcohol use. Recent exposure to intimate partner violence (adjusted odds ratio (aOR) = 2.08; 95% confidence interval (CI): 1.37, 3.18) and hazardous tobacco use (aOR = 5.03; 95% CI: 2.97, 8.52) were significant correlates of hazardous alcohol use. After controlling for potential psychosocial confounders, hazardous alcohol use remained associated with lower infant weight-for-age (B = -0.35, 95% CI: -0.56, -0.14), height-for-age (B = -0.46, 95% CI: -0.76, -0.17), and head-circumference-for-age z-scores (B = -0.43, 95% CI: -0.69, -0.17).
conclusionsInterventions to reduce hazardous alcohol use among pregnant women in South Africa are needed to prevent alcohol-related infant growth restrictions. As these growth deficits may lead to neurodevelopmental consequences, it is critical to identify alcohol-related growth restrictions at birth and link exposed infants to early interventions for neurodevelopment.
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