Evidence map›Paper›PMID 29197086›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2018

Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents.

Barbara Ruggeri, Christine Macare, Serena Stopponi, Tianye Jia, Fabiana M Carvalho, Gabriel Robert, Tobias Banaschewski, Arun L W Bokde, Uli Bromberg, Christian Büchel and 25 more

Open access · bronzeAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of child psychology and psychiatry, and allied disciplines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Epigenetic Modulation of Opioid Receptors by Drugs of Abuse.International journal of molecular sciences · 2022
    Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 16 institutions in 8 countries.

Barbara RuggeriInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Christine MacareInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Serena StopponiSchool of Pharmacy, University of Camerino, Camerino, Italy.
Tianye JiaInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Fabiana M CarvalhoInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Gabriel RobertInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Tobias BanaschewskiCentral Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Arun L W BokdeInstitute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Uli BrombergUniversitaetsklinikum Hamburg Eppendorf, Hamburg, Germany.
Christian BüchelUniversitaetsklinikum Hamburg Eppendorf, Hamburg, Germany.
Anna CattrellInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Patricia J ConrodInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Sylvane DesrivièresInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Herta FlorDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Vincent FrouinNeurospin, Commissariat à l'Energie Atomique et aux Energies Alternatives, Paris, France.
Jürgen GallinatDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Hugh GaravanInstitute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Penny GowlandSchool of Psychology, University of Nottingham, Nottingham, UK.
Andreas HeinzDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Bernd IttermannPhysikalisch-Technische Bundesanstalt (PTB), Braunschweig und Berlin, Germany.
Jean Luc MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM CEA Unit 1000 "Imaging & Psychiatry", University Paris Sud, Orsay, France.
Marie-Laure Paillère MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM CEA Unit 1000 "Imaging & Psychiatry", University Paris Sud, Orsay, France.
Frauke NeesDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Dimitri Papadopoulos-OrfanosNeurospin, Commissariat à l'Energie Atomique et aux Energies Alternatives, Paris, France.
Tomáš PausSchool of Psychology, University of Nottingham, Nottingham, UK.
Luise PoustkaCentral Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Michael N SmolkaDepartment of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
Nora C VetterDepartment of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
Henrik WalterDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Robert WhelanDepartment of Psychology, University College Dublin, Dublin, Ireland.
Wolfgang H SommerCentral Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Georgy BakalkinDivision of Biological Research on Drug Dependence, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
Roberto CiccocioppoSchool of Pharmacy, University of Camerino, Camerino, Italy.
Gunter SchumannInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
IMAGEN consortium
Psychiatry Research Trust · GBKing's College London · GBCharité - Universitätsmedizin Berlin · DEHeidelberg University · DECommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRInserm · FRTrinity College Dublin · IETU Dresden · DEUniversità di Camerino · ITUniversity Medical Center Hamburg-Eppendorf · DEUniversity of Nottingham · GBCentral Institute of Mental Health · DEPhysikalisch-Technische Bundesanstalt · DEUniversity College Dublin · IEUniversity Hospital Heidelberg · DEUppsala University · SE

Funding

Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Axon, Testosterone and Mental Health during AdolescenceR01MH085772 · NIMH · BAYCREST CENTRE FOR GERIATRIC CARE · PI PAUS, TOMAS · 2010 to 2014
$1.5M
Influence of P-glycoprotein in treating brain tumorsR01CA093558 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI MILLER, DONALD W · 2004 to 2006
$568k
Department of HealthMedical Research Council 93558Medical Research Council G0901858Medical Research Council MR/N000390/1NIBIB NIH HHS U54 EB020403NIMH NIH HHS R01 MH085772Wellcome Trust
6 · The paper itself

Abstract

backgroundNociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome-wide methylation analysis, we recently identified an association of a methylated region in the OPRL1 gene with alcohol-use disorders.

methodsHere, we investigate the biological basis of this observation by analysing psychosocial stressors, methylation of the OPRL1 gene, brain response during reward anticipation and alcohol drinking in 660 fourteen-year-old adolescents of the IMAGEN study. We validate our findings in marchigian sardinian (msP) alcohol-preferring rats that are genetically selected for increased alcohol drinking and stress sensitivity.

resultsWe found that low methylation levels in intron 1 of OPRL1 are associated with higher psychosocial stress and higher frequency of binge drinking, an effect mediated by OPRL1 methylation. In individuals with low methylation of OPRL1, frequency of binge drinking is associated with stronger BOLD response in the ventral striatum during reward anticipation. In msP rats, we found that stress results in increased alcohol intake and decreased methylation of OPRL1 in the nucleus accumbens.

conclusionsOur findings describe an epigenetic mechanism that helps to explain how psychosocial stress influences risky alcohol consumption and reward processing, thus contributing to the elucidation of biological mechanisms underlying risk for substance abuse.

Indexed as

Binge DrinkingRewardStress, PsychologicalUnderage DrinkingAdolescentAnimalsAnticipation, PsychologicalDNA MethylationEpigenesis, GeneticFemaleHumansMagnetic Resonance ImagingMaleNociceptin ReceptorRatsReceptors, OpioidNociceptin ReceptorReceptors, Opioidadolescencebinge drinkingnucleus accumbensOPRL1 methylationstressful life events

Identifiers

PMID29197086
PMCPMC5975104
OpenAlexW2772224806

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.