ArticleNeurochemical research2018
Behavioral and Biochemical Effects of N-Acetylcysteine in Zebrafish Acutely Exposed to Ethanol.
Article in Neurochemical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 36 citations in OpenAlex.
- Modulation of Caffeine-Induced Behavioral Alterations by N-Acetylcysteine in a Pharmacological Challenge Model.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Neurobehavioral and Oxidative Stress Effects of SiOBiomedicines · 2025Article
- Naltrexone Alters Neurochemical and Behavioral Parameters in a Zebrafish Model of Repeated Alcohol Exposure.Neurochemical research · 2025Article
- N-Acetylcysteine Ineffective in Alleviating Hangover from Binge Drinking: A Clinical Study.Toxics · 2024Article
- Effects of N-acetylcysteine and acetyl-L-carnitine on acute PTZ-induced seizures in larval and adult zebrafish.Pharmacological reports : PR · 2023Article
- Effects of N-acetylcysteine amide on anxiety and stress behavior in zebrafish.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- N-Acetylcysteine Reverses Anxiety and Oxidative Damage Induced by Unpredictable Chronic Stress in Zebrafish.Molecular neurobiology · 2019Article
- Repeated ethanol exposure increases anxiety-like behaviour in zebrafish during withdrawal.PeerJ · 2019Article
- N-acetyl cysteine in the treatment of alcohol use disorder in patients with liver disease: Rationale for further research.Expert opinion on investigational drugs · 2018Review
- Anxiolytic and anti-stress effects of acute administration of acetyl-L-carnitine in zebrafish.PeerJ · 2018Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Alcohol hangover refers to unpleasant symptoms experienced as a direct consequence of a binge drinking episode. The effects observed in this condition are related to the increase in alcohol metabolites and imbalance in oxidative status. N-acetylcysteine (NAC) is a mucolytic agent and an antidote for paracetamol overdose. Preclinical and clinical studies have shown that NAC is a multi-target drug acting through neuroprotective, antioxidant and neurotrophic mechanisms as well as a glutamate modulator. The aim of this study was to investigate the effects of NAC in zebrafish acutely exposed to ethanol (EtOH). Animals pretreated or not with NAC (1 mg/L, 10 min) were exposed for 60 min to standard tank water (EtOH-) or to 1% EtOH (EtOH+) to evaluate anxiety-like behavior and locomotion in the novel tank test and oxidative damage in the brain. Zebrafish (Danio rerio) exposed to EtOH displayed a decrease in the distance traveled, crossings, entries and time spent in the top area in the novel tank test. Exposure to EtOH also caused oxidative damage, shown by increased lipid peroxidation, decreased non-protein thiols and increased production of reactive oxygen species (DCF assay). NAC prevented both the behavioral alterations and the oxidative stress observed in EtOH+ animals. Given the effects of NAC in preventing the acute behavioral and biochemical effects of EtOH, additional studies are warranted to further investigate the basis of its anecdotal use to prevent hangover.
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Registered trials
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