Evidence map›Paper›PMID 29196947›Full record

ArticleClinical oral investigations2018

Effect of bleaching agent extracts on murine macrophages.

Aletéia M M Fernandes, Polyana G F Vilela, Marcia C Valera, Carola Bolay, Karl Anton Hiller, Helmut Schweikl, Gottfried Schmalz

Registry-linked trialOpen access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Clinical oral investigations, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06606236 (Neuropeptide Y Regulates Tooth Bleaching Agent-induced Neurogenic Pulp Inflammation), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06606236 nacompletednot on this mapstarted 2024, after this paper: background citation

Neuropeptide Y Regulates Tooth Bleaching Agent-induced Neurogenic Pulp Inflammation: An In-Vivo Study

TypeinterventionalSponsorInstitucion Universitaria Colegios de ColombiaRan2024 to 2024Enrolled40ConditionsNeurogenic Inflammation, Dental Pulp DiseaseArmsH2O2 at 35% for 8 minutes, H2O2 at 40% for 20 minutes, H2O2 at 25% plus cold blue light for 15 minutes
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Aletéia M M FernandesDepartment of Health Sciences, Endodontics Division, Nove de Julho University (UNINOVE), São Paulo, Brazil.
Polyana G F VilelaDepartment of Bioscience and Oral Diagnosis, Microbiology Division, São José dos Campos Dental School, State University of São Paulo, UNESP, Av. Eng. Francisco José Longo, 777-Jardim Sao Dimas, São José dos Campos, SP, 12245-000, Brazil.
Marcia C ValeraDepartment of Restorative Dentistry, Endodontic Division, São José dos Campos Dental School, State University of São Paulo UNESP, Av. Eng. Francisco José Longo, 777-Jardim Sao Dimas, São José dos Campos, SP, 12245-000, Brazil.
Carola BolayDepartment of Conservative Dentistry and Periodontology, University Hospital Regensburg, University of Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
Karl Anton HillerDepartment of Conservative Dentistry and Periodontology, University Hospital Regensburg, University of Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
Helmut SchweiklDepartment of Conservative Dentistry and Periodontology, University Hospital Regensburg, University of Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
Gottfried SchmalzDepartment of Conservative Dentistry and Periodontology, University Hospital Regensburg, University of Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany. Gottfried.Schmalz@ukr.de.ORCID http://orcid.org/0000-0001-8082-7662
University Hospital Regensburg · DEUniversidade de São Paulo · BRUniversidade Nove de Julho · BRUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study was to evaluate the cytotoxicity and the influence of bleaching agents on immunologically cell surface antigens of murine macrophages in vitro. MATERIALS AND

methodsRAW 264.7 cells were exposed to bleaching gel extracts (40% hydrogen peroxide or 20% carbamide peroxide) and different H

resultsExtracts of bleaching agents were cytotoxic for cells after a 1-h exposure; cells could not recover after 24 h. This effect can be mitigated by the antioxidant NAC and increased by BSO, an inhibitor of glutathione (GSH) synthesis. LPS stimulated expression of all surface markers and TNF-α production. Exposure to bleaching agent extracts and H

conclusionsExtracts of bleaching agents were irreversibly cytotoxic to macrophages after a 1-h exposure. Only the expression of CD54 was upregulated. The reactions are mediated by the non-enzymatic antioxidant GSH. CLINICAL RELEVANCE: The addition of an antioxidant can downregulate unfavorable effects of dental bleaching.

Indexed as

AcetylcysteineAnimalsAntigens, SurfaceBleaching AgentsButhionine SulfoximineCarbamide PeroxideCells, CulturedCell SurvivalEnzyme-Linked Immunosorbent AssayFlow CytometryHydrogen PeroxideMacrophagesMicePeroxidesTooth BleachingTumor Necrosis Factor-alphaAcetylcysteineAntigens, SurfaceBleaching AgentsButhionine SulfoximineCarbamide PeroxideHydrogen PeroxidePeroxidesTumor Necrosis Factor-alphaUreaCytokinesCytotoxicityDental bleachingHydrogen peroxideImmunology

Identifiers

PMID29196947
OpenAlexW2775313484

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.