Evidence map›Paper›PMID 29196893›Full record

ArticleJournal of industrial microbiology & biotechnology2018

High yield production of four-carbon dicarboxylic acids by metabolically engineered Escherichia coli.

Irene Martinez, Haijun Gao, George N Bennett, Ka-Yiu San

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of industrial microbiology & biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Tunable and Efficient COBiotechnology and bioengineering · 2026
    Article
  3. Review
  4. Review
  5. EngineeringBiotechnology reports (Amsterdam, Netherlands) · 2022
    Article
  6. Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Irene MartinezDepartment of Bioengineering, Rice University, 6500 Main Street, Houston, TX, 77030, USA.
Haijun GaoDepartment of Bioengineering, Rice University, 6500 Main Street, Houston, TX, 77030, USA.
George N BennettDepartment of BioSciences, Rice University, Houston, TX, USA.
Ka-Yiu SanDepartment of Bioengineering, Rice University, 6500 Main Street, Houston, TX, 77030, USA. ksan@rice.edu.ORCID 0000-0002-1449-4406
Rice University · USPontificia Universidad Católica de Valparaíso · CL

Funding

National Science Foundation CBET-0828516NIH HHS GM090152)
6 · The paper itself

Abstract

Several metabolic engineered Escherichia coli strains were constructed and evaluated for four-carbon dicarboxylic acid production. Fumarase A, fumarase B and fumarase C single, double and triple mutants were constructed in a ldhA adhE mutant background overexpressing the pyruvate carboxylase from Lactococcus lactis. All the mutants produced succinate as the main four-carbon (C4) dicarboxylic acid product when glucose was used as carbon source with the exception of the fumAC and the triple fumB fumAC deletion strains, where malate was the main C4-product with a yield of 0.61-0.67 mol (mole glucose)

Indexed as

Alcohol DehydrogenaseCarbonDicarboxylic AcidsEscherichia coliFumarate HydrataseGlucoseLactococcus lactisL-Lactate DehydrogenaseMalatesMetabolic EngineeringMutationSuccinic AcidAlcohol DehydrogenaseCarbonDicarboxylic AcidsFumarate HydrataseGlucoseL-Lactate DehydrogenaseMalatesmalic acidSuccinic AcidDicarboxylic acidsEscherichia coliMalateMetabolic engineeringSuccinate

Identifiers

PMID29196893
OpenAlexW2772715994

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.