Evidence map›Paper›PMID 29196775›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2018

A health economic simulation model for the clinical management of osteoporosis.

E Jonsson, A Hansson-Hedblom, Ö Ljunggren, K Åkesson, A Spångeus, J A Kanis, F Borgström

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Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

E JonssonQuantify Research, Hantverkargatan 8, 112 21, Stockholm, SE, Sweden. emma.jonsson@quantifyresearch.com.ORCID 0000-0002-9135-209X
A Hansson-HedblomQuantify Research, Hantverkargatan 8, 112 21, Stockholm, SE, Sweden.
Ö LjunggrenDepartment of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden.
K ÅkessonDepartment of Clinical Sciences, Clinical and Molecular Osteoporosis Unit, Lund University, Malmö, Sweden.
A SpångeusDepartment of Endocrinology, Medicine and Health, Linköping University, Linköping, Sweden.
J A KanisUniversity of Sheffield, Sheffield, UK.
F BorgströmQuantify Research, Hantverkargatan 8, 112 21, Stockholm, SE, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective was to estimate the burden of osteoporosis in Sweden based on current clinical practice and the cost-effectiveness of improvements in the management of osteoporosis over the clinical management compared to current clinical practice. Results showed that better compliance to treatment guidelines is associated with better projected outcomes and cost-savings.

introductionThe purpose of this study is to estimate the burden of osteoporosis in Sweden based on current clinical practice and the cost-effectiveness of improvements in the management of osteoporosis over the clinical management compared to current clinical practice.

methodsThe analysis was carried out using a model that simulates the individual patients considered for pharmacological treatment during 1 year and their projected osteoporosis treatment pathway, quality-adjusted life years (QALYs) and costs over their remaining lifetime. All patients regardless of treatment or no treatment were simulated. Information on current management of osteoporosis in terms of patient characteristics and treatment patterns were derived from a Swedish osteoporosis research database based on national registers and patient records. Current (standard) clinical management was compared with alternative scenarios mirroring Swedish treatment guidelines.

resultsThe national burden in terms of lost QALYs was estimated at 14,993 QALYs and the total economic cost at €776M. Scenario analyses showed that 382-3864 QALYs could be gained at a cost/QALY ranging from cost-saving to €31368, depending on the scenario. The margin of investment, i.e. the maximum amount that could be invested in the healthcare system to achieve these improvements up to the limit of the willingness to pay/QALY, was estimated at €199M on a population level (€3,634/patient).

conclusionsThe analysis showed that better compliance to treatment guidelines is associated with better projected outcomes and cost-savings. From a cost-effectiveness perspective, there is also considerable room for investment to achieve these improvements in the management of osteoporosis.

Indexed as

Models, EconometricAgedAged, 80 and overBone DensityBone Density Conservation AgentsCost-Benefit AnalysisDrug MonitoringDrug SubstitutionFemaleHealth Care CostsHumansMaleMiddle AgedOsteoporosisOsteoporotic FracturesQuality-Adjusted Life YearsBone Density Conservation AgentsCostFractureOsteoporosisQuality-of-lifeRegisterSweden

Identifiers

PMID29196775

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.