ArticleJournal of perinatology : official journal of the California Perinatal Association2018
Continuous positive airway pressure delivery during less invasive surfactant administration: a physiologic study.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Non-invasive open lung strategy in delivery room: randomized controlled trial (OpenCPAP-DR).European journal of pediatrics · 2025Trial
- Less Invasive Surfactant Administration (LISA) versus Intubation Surfactant Extubation (InSurE) technique using higher volume surfactant in management of neonates with respiratory distress syndrome: an open-label randomized controlled trial.European journal of pediatrics · 2025Trial
- Minimally invasive surfactant therapy versus InSurE in preterm neonates of 28 to 34 weeks with respiratory distress syndrome on non-invasive positive pressure ventilation-a randomized controlled trial.European journal of pediatrics · 2020Trial
- Surfactant administration in late preterm and term neonates: is LISA ready for routine use?European journal of pediatrics · 2026Review
- Dexmedetomidine for LISA procedure: a prospective observational single center experience.Italian journal of pediatrics · 2026Observational
- Low invasive surfactant administration by videolaringoscopy: a feasibility study.Italian journal of pediatrics · 2025Article
- Effect of different CPAP levels on ultrasound-assessed lung aeration and gas exchange in neonates.Respiratory research · 2024Observational
- Less invasive surfactant administration methods: Who, what and how.Journal of perinatology : official journal of the California Perinatal Association · 2024Review
- Noise Produced by Neonatal Ventilators Inside and Outside of the Incubators.Respiratory care · 2023Article
- Should less invasive surfactant administration (LISA) become routine practice in US neonatal units?Pediatric research · 2023Review
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- Alternative Methods of Surfactant Administration in Preterm Infants with Respiratory Distress Syndrome: State of the Art.Turkish archives of pediatrics · 2021Article
- Premedication with ketamine or propofol for less invasive surfactant administration (LISA): observational study in the delivery room.European journal of pediatrics · 2021Observational
- Less invasive surfactant administration: all that glitters is not gold.European journal of pediatrics · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe sought to investigate the pressure delivery during less invasive surfactant administration, as we hypothesize that it might be reduced. STUDY
designPhysiologic in vitro study in a ventilation lab, using different pressure generators, levels, and leaks in a model of neonatal airways/lung mimicking mechanical characteristics of respiratory distress syndrome. Pressure was measured at the lung and verified in vivo measuring pharyngeal pressure in 19 neonates under same conditions. Data were analyzed using repeated measures-analysis of variance.
resultsPressure delivery in vitro is significantly and variably reduced during minimally invasive surfactant administration: pressure loss is ≈99% and ≈10-97%, during mouth opening and closure, respectively. Pressure loss seems independent from the type of CPAP and interface. In vivo measurements showed similar pressure drops.
conclusionsPressure transmission during minimally invasive surfactant administration is significantly reduced or totally absent. Pressure drop occurs despite the increased airway resistances and the airflow limitation due to the tracheal catheterization, but is independent from the type of pressure generator and interface.
Indexed as
Identifiers
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Registered trials
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