Evidence map›Paper›PMID 29196727›Full record

ArticleScientific reports2017

Hypersensitivity of BRCA2 deficient cells to rosemary extract explained by weak PARP inhibitory activity.

Cathy Su, Jeffrey P Gius, Julia Van Steenberg, Alexis H Haskins, Kazuki Heishima, Chisato Omata, Masahiro Iwayama, Mami Murakami, Takashi Mori, Kohji Maruo and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. The Effect of Green and Black Tea Polyphenols onInternational journal of molecular sciences · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Cathy SuDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, 80523, USA.
Jeffrey P GiusDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, 80523, USA.
Julia Van SteenbergDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, 80523, USA.
Alexis H HaskinsDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, 80523, USA.
Kazuki HeishimaFaculty of Applied Biological Sciences, United Department of Veterinary Medicine, Gifu University, 1-1, Yanagido Gifu, 501-1193, Japan.
Chisato OmataDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, 80523, USA.
Masahiro IwayamaFaculty of Applied Biological Sciences, United Department of Veterinary Medicine, Gifu University, 1-1, Yanagido Gifu, 501-1193, Japan.
Mami MurakamiFaculty of Applied Biological Sciences, United Department of Veterinary Medicine, Gifu University, 1-1, Yanagido Gifu, 501-1193, Japan.
Takashi MoriFaculty of Applied Biological Sciences, United Department of Veterinary Medicine, Gifu University, 1-1, Yanagido Gifu, 501-1193, Japan.
Kohji MaruoFaculty of Applied Biological Sciences, United Department of Veterinary Medicine, Gifu University, 1-1, Yanagido Gifu, 501-1193, Japan.
Takamitsu A KatoDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, 80523, USA. takamitsu.kato@colostate.edu.
Colorado State University · USGifu University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rosemary extract is used in food additives and traditional medicine and has been observed to contain anti-tumor activity. In this study, rosemary extract is hypothesized to induce synthetic lethality in BRCA2 deficient cells by PARP inhibition. Chinese hamster lung V79 cells and its mutant cell lines, V-C8 (BRCA2 deficient) and V-C8 with BRCA2 gene correction were used. Rosemary extract and its major constituent chemicals were tested for their cytotoxicity by colony formation assay in cells of different BRCA2 status. The latter chemicals were tested for inhibitory effect of poly (ADP-ribose) polymerase (PARP) activity in vitro and in vivo. Rosemary has shown selective cytotoxicity against V-C8 cells (IC

Indexed as

AbietanesAnimalsBRCA2 ProteinCell SurvivalCHO CellsCinnamatesCricetinaeCricetulusDepsidesDNA DamagePlant ExtractsPoly(ADP-ribose) Polymerase InhibitorsPoly(ADP-ribose) PolymerasesRosmarinic AcidRosmarinusAbietanesBRCA2 ProteincarnosolCinnamatesDepsidesPlant ExtractsPoly(ADP-ribose) Polymerase InhibitorsPoly(ADP-ribose) PolymerasesRosmarinic Acidsalvin

Identifiers

PMID29196727
PMCPMC5711971
OpenAlexW2769160638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.