ArticleInternational journal of impotence research2018
Relationship between erectile dysfunction and the neutrophil to lymphocyte and platelet to lymphocyte ratios.
Article in International journal of impotence research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 39 citations in OpenAlex.
- Inflammatory Markers Associated with Antidepressant-Related Side Effects in Patients with Major Depressive Disorder: A Cross-Sectional Study.Journal of clinical medicine · 2026Article
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- Novel predictive factor for erectile dysfunction: systemic immune inflammation index.International journal of impotence research · 2025Article
- Novel indicator for erectile dysfunction: the CALLY index, evidence from data of NHANES 2001-2004.Frontiers in endocrinology · 2025Article
- Neutrophil percentage-to-albumin ratio as a novel hematologic biomarker for predicting arteriogenic erectile dysfunction.Frontiers in endocrinology · 2025Article
- The associations among platelet count, mean platelet volume, and erectile dysfunction: an observational and Mendelian randomization study.Sexual medicine · 2024Article
- Association between the systemic immune-inflammation index and erectile dysfunction: A cross-sectional study.Immunity, inflammation and disease · 2024Article
- Tumor necrosis factor-alpha, transforming growth factor-beta, degree of lower urinary tract symptoms as predictors of erectile dysfunction in benign prostatic hyperplasia patients.Asian journal of urology · 2024Article
- Association between erectile dysfunction and the predicted 10-year risk for atherosclerosis cardiovascular disease among U.S. men: a population-based study from the NHANES 2001-2004.Frontiers in endocrinology · 2024Article
- Predictive value of Prognostic Nutritional Index (PNI) for the severity of vasculogenic erectile dysfunction.International urology and nephrology · 2023Article
- Inflammatory biomarkers may predict response to phosphodiesterase type 5 inhibitor treatment in patients with erectile dysfunction.Investigative and clinical urology · 2023Article
- Association between neutrophil to lymphocyte ratio and erectile dysfunction among US males: a population-based cross-sectional study.Frontiers in endocrinology · 2023Article
- The Relationship Between Hematologic Parameters and Erectile Dysfunction.Sexual medicine · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The most important cause of erectile dysfunction (ED) among aging men is organic disease due to vascular disturbance that is often caused by atherosclerosis. Recently, studies have shown that atherosclerosis can manifest as an active inflammatory process rather than as passive vascular injury caused by lipid infiltration. Our study aimed to examine the association of ED with the neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio (PLR), both of which are markers of inflammation. Between December 2014 and May 2015, 101 male patients aged 40-70 years who were seen at our institute due to ED were included in this study. Thirty-one sexually active men with similar clinical and demographic characteristics without ED were included in our study as a control group. The control and patient groups were compared with respect to their NLR and PLR values as well as other hormonal, biochemical, hematological parameters. The median ages of the patient and control groups were 49 (40-69) and 48 (43-65) years old, respectively. Comorbidities such as hypertension, diabetes, chronic obstructive pulmonary disease (COPD), and coronary artery disease were not significantly different between the groups (p > 0.05). The neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios were significantly higher in the patient group than in the control group (p < 0.05). Furthermore, the detected CRP levels were also significantly higher in the patient group than in the control group (p < 0.001). In the correlation analysis, the NLR, PLR, and CRP levels were negatively correlated with the IIEF-5 scores. A multivariate analysis was performed to determine the independent predictors of ED. PLR was identified as an independent predictor for ED. The neutrophil-to-lymphocyte and especially platelet-to-lymphocyte ratios are correlated with a diagnosis of ED, and these ratios could serve as practical parameters that will not elicit additional costs.
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