ArticleScientific reports2017
Network Properties in Transitions of Consciousness during Propofol-induced Sedation.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 146 citations in OpenAlex.
- Depth of anesthesia monitoring: Current evidence, clinical impact, and future directions.The Journal of international medical research · 2026Review
- Article
- Neurophysiological connectomic signatures of consciousness during propofol-induced general anesthesia.Cell reports. Medicine · 2026Article
- Abnormal Enhanced Gamma Synchronization in the Default Mode Network Associated With Chronic Pain.European journal of neurology · 2025Article
- Activation of Glutamatergic Neurons in the Supramammillary Nucleus Promotes the Recovery of Consciousness under Sevoflurane Anesthesia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Activation of CaMKIICell biology and toxicology · 2025Article
- A mental state aware brain computer interface for adaptive control of electric powered wheelchair.Scientific reports · 2025Article
- Evaluation of putative signatures of consciousness using specific definitions of responsiveness, connectedness, and consciousness.British journal of anaesthesia · 2024Article
- Propofol-mediated Unconsciousness Disrupts Progression of Sensory Signals through the Cortical Hierarchy.Journal of cognitive neuroscience · 2024Article
- Elevating understanding: Linking high-altitude hypoxia to brain aging through EEG functional connectivity and spectral analyses.Network neuroscience (Cambridge, Mass.) · 2024Article
- Analogous cortical reorganization accompanies entry into states of reduced consciousness during anesthesia and sleep.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Rapid thalamocortical network switching mediated by cortical synchronization underlies propofol-induced EEG signatures: a biophysical model.Journal of neurophysiology · 2023Article
- Development of EEG connectivity from preschool to school-age children.Frontiers in neuroscience · 2023Article
- Prognostication after cardiac arrest: how EEG and evoked potentials may improve the challenge.Annals of intensive care · 2022Review
- How general anesthetics work: from the perspective of reorganized connections within the brain.Korean journal of anesthesiology · 2022Review
- EEG functional connectivity is sensitive for nitrogen narcosis at 608 kPa.Scientific reports · 2022Article
- Electroencephalography in delirium assessment: a scoping review.BMC neurology · 2022Article
- Propofol-induced Unresponsiveness Is Associated with a Brain Network Phase Transition.Anesthesiology · 2022Article
- Quantifying arousal and awareness in altered states of consciousness using interpretable deep learning.Nature communications · 2022Article
- 2020 International brain-computer interface competition: A review.Frontiers in human neuroscience · 2022Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reliable electroencephalography (EEG) signatures of transitions between consciousness and unconsciousness under anaesthesia have not yet been identified. Herein we examined network changes using graph theoretical analysis of high-density EEG during patient-titrated propofol-induced sedation. Responsiveness was used as a surrogate for consciousness. We divided the data into five states: baseline, transition into unresponsiveness, unresponsiveness, transition into responsiveness, and recovery. Power spectral analysis showed that delta power increased from responsiveness to unresponsiveness. In unresponsiveness, delta waves propagated from frontal to parietal regions as a traveling wave. Local increases in delta connectivity were evident in parietal but not frontal regions. Graph theory analysis showed that increased local efficiency could differentiate the levels of responsiveness. Interestingly, during transitions of responsive states, increased beta connectivity was noted relative to consciousness and unconsciousness, again with increased local efficiency. Abrupt network changes are evident in the transitions in responsiveness, with increased beta band power/connectivity marking transitions between responsive states, while the delta power/connectivity changes were consistent with the fading of consciousness using its surrogate responsiveness. These results provide novel insights into the neural correlates of these behavioural transitions and EEG signatures for monitoring the levels of consciousness under sedation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.