Evidence map›Paper›PMID 29196621›Full record

ArticleNature communications2017

Remodelling of the gut microbiota by hyperactive NLRP3 induces regulatory T cells to maintain homeostasis.

Xiaomin Yao, Chenhong Zhang, Yue Xing, Guang Xue, Qianpeng Zhang, Fengwei Pan, Guojun Wu, Yingxin Hu, Qiuhong Guo, Ailing Lu and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 3 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 3 syntheses or guidelines pooled it, 192 citations in OpenAlex.

  1. Pooled it
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  16. Oral Intake ofBiomedicines · 2025
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66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

Xiaomin YaoKey Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai, 200031, China.ORCID http://orcid.org/0000-0003-4045-8836
Chenhong ZhangState Key Laboratory of Microbial Metabolism, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Yue XingKey Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai, 200031, China.
Guang XueKey Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai, 200031, China.
Qianpeng ZhangState Key Laboratory of Microbial Metabolism, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Fengwei PanState Key Laboratory of Microbial Metabolism, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Guojun WuState Key Laboratory of Microbial Metabolism, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Yingxin HuState Key Laboratory of Microbial Metabolism, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Qiuhong GuoKey Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai, 200031, China.
Ailing LuKey Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai, 200031, China.
Xiaoming ZhangKey Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai, 200031, China.
Rongbin ZhouDepartment of Immunology, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027, China.
Zhigang TianDepartment of Immunology, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027, China.
Benhua ZengDepartment of Laboratory Animal Science, College of Basic Medical Sciences, Third Military Medical University, Chongqing, 400038, China.
Hong WeiDepartment of Laboratory Animal Science, College of Basic Medical Sciences, Third Military Medical University, Chongqing, 400038, China.
Warren StroberMucosal Immunity Section, Laboratory for Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Liping ZhaoState Key Laboratory of Microbial Metabolism, Department of Biological Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China. lpzhao@sjtu.edu.cn.
Guangxun MengKey Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai, 200031, China. gxmeng@ips.ac.cn.
Chinese Academy of Sciences · CNShanghai Jiao Tong University · CNArmy Medical University · CNUniversity of Science and Technology of China · CNNational Institutes of Health · US

Funding

Immunoregulatory Defects In Inflammatory Bowel DiseaseZIAAI000354 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI STROBER, WARREN · 2009 to 2025
$8.7M
6 · The paper itself

Abstract

Inflammasomes are involved in gut homeostasis and inflammatory pathologies, but the role of NLRP3 inflammasome in these processes is not well understood. Cryopyrin-associated periodic syndrome (CAPS) patients with NLRP3 mutations have autoinflammation in skin, joints, and eyes, but not in the intestine. Here we show that the intestines of CAPS model mice carrying an Nlrp3

Indexed as

Gastrointestinal MicrobiomeAnimalsCryopyrin-Associated Periodic SyndromesHomeostasisHumansInflammasomesInterleukin-1betaInterleukin-8IntestinesMaleMice, Inbred C57BLMutationNLR Family, Pyrin Domain-Containing 3 ProteinT-Lymphocytes, RegulatoryInflammasomesInterleukin-1betaInterleukin-8NLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouse

Identifiers

PMID29196621
PMCPMC5711854
OpenAlexW2770964951

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.