Evidence map›Paper›PMID 29196604›Full record

ReviewThe Journal of biological chemistry2018

CaMKII regulates the depalmitoylation and synaptic removal of the scaffold protein AKAP79/150 to mediate structural long-term depression.

Kevin M Woolfrey, Heather O'Leary, Dayton J Goodell, Holly R Robertson, Eric A Horne, Steven J Coultrap, Mark L Dell'Acqua, K Ulrich Bayer

Open access · hybridAbstract readReview
In one paragraph

Review in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 57 citations in OpenAlex.

  1. Review
  2. Long-term potentiation and long-term depression are both impaired afterBiomedical physics & engineering express · 2025
    Article
  3. Palmitoylation in cardiovascular diseases: Molecular mechanism and therapeutic potential.International journal of cardiology. Heart & vasculature · 2025
    Review
  4. Article
  5. Review
  6. Mechanisms and functions of protein S-acylation.Nature reviews. Molecular cell biology · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Role of CaFrontiers in molecular neuroscience · 2022
    Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Kevin M WoolfreyFrom the Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045.
Heather O'LearyFrom the Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045.
Dayton J GoodellFrom the Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045.
Holly R RobertsonFrom the Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045.
Eric A HorneFrom the Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045.
Steven J CoultrapFrom the Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045.
Mark L Dell'AcquaFrom the Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045 mark.dellacqua@ucdenver.edu.
K Ulrich BayerFrom the Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045 ulli.bayer@ucdenver.edu.
University of Colorado Denver · US

Funding

Development of Psychopathology, Psychobiology, & BehaviorT32MH015442 · NIMH · UNIVERSITY OF COLORADO DENVER · PI JASON R TREGELLAS · 1985 to 2026
$10.2M
ZEBRAFISH TRANSGENIC CORE - ROCKY MOUNTAIN NEUROLOGICAL DISORDERS CORE CENTERP30NS048154 · NINDS · UNIVERSITY OF COLORADO DENVER · PI RIBERA, ANGELES BADELL · 2004 to 2020
$10.1M
Regulation of Calcium-permeable AMPA Receptors by AKAP79 Postsynaptic SignalingR01NS040701 · NINDS · UNIVERSITY OF COLORADO DENVER · PI DELL'ACQUA, MARK L · 2001 to 2023
$7.7M
PREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM007635 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI DELL'ACQUA, MARK L · 1985 to 2023
$6.1M
CaMKII substrate-selection in opposing forms of synaptic plasticityR01NS081248 · NINDS · UNIVERSITY OF COLORADO DENVER · PI K. Ulrich Bayer · 2013 to 2026
$4.9M
CaMKII in global cerebral ischemiaR01NS080851 · NINDS · UNIVERSITY OF COLORADO DENVER · PI BAYER, K. ULRICH, HERSON, PACO S · 2013 to 2017
$2.1M
NIGMS NIH HHS T32 GM007635NIMH NIH HHS T32 MH015442NINDS NIH HHS P30 NS048154NINDS NIH HHS R01 NS040701NINDS NIH HHS R01 NS080851NINDS NIH HHS R01 NS081248
6 · The paper itself

Abstract

Both long-term potentiation (LTP) and depression (LTD) of excitatory synapse strength require the Ca

Indexed as

LipoylationLong-Term PotentiationLong-Term Synaptic DepressionProtein Processing, Post-TranslationalA Kinase Anchor ProteinsAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2HumansSpineSynapsesAKAP5 protein, humanA Kinase Anchor ProteinsCalcium-Calmodulin-Dependent Protein Kinase Type 2AKAP79/150Ca2+/calmodulin-dependent protein kinase II (CaMKII)calmodulin (CaM)dendritic spinelong-term depression (LTD)synapsesynaptic plasticity

Identifiers

PMID29196604
PMCPMC5798287
OpenAlexW2771393216

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.