Evidence map›Paper›PMID 29196581›Full record

ArticleNeurology2018

Increased midlife triglycerides predict brain β-amyloid and tau pathology 20 years later.

Katarina Nägga, Anna-Märta Gustavsson, Erik Stomrud, Daniel Lindqvist, Danielle van Westen, Kaj Blennow, Henrik Zetterberg, Olle Melander, Oskar Hansson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 114 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Association of type 2 diabetes treatment status with in vivo biomarkers of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  6. Amyloid-beta (1-40) peptide is associated with systemic metabolic health.European journal of clinical investigation · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Katarina NäggaFrom the Clinical Memory Research Unit (K.N., A.-M.G., E.S., O.H.) and Clinical Research Centre (O.M.), Department of Clinical Sciences Malmö, Lund University; Memory Clinic (K.N., A.-M.G., E.S., O.H.), Skåne University Hospital, Malmö; Psychiatry (D.L.) and Diagnostic Radiology (D.v.W.), Department of Clinical Sciences Lund, Lund University; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK. katarina.nagga@med.lu.se oskar.hansson@med.lu.se.
Anna-Märta GustavssonFrom the Clinical Memory Research Unit (K.N., A.-M.G., E.S., O.H.) and Clinical Research Centre (O.M.), Department of Clinical Sciences Malmö, Lund University; Memory Clinic (K.N., A.-M.G., E.S., O.H.), Skåne University Hospital, Malmö; Psychiatry (D.L.) and Diagnostic Radiology (D.v.W.), Department of Clinical Sciences Lund, Lund University; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK.
Erik StomrudFrom the Clinical Memory Research Unit (K.N., A.-M.G., E.S., O.H.) and Clinical Research Centre (O.M.), Department of Clinical Sciences Malmö, Lund University; Memory Clinic (K.N., A.-M.G., E.S., O.H.), Skåne University Hospital, Malmö; Psychiatry (D.L.) and Diagnostic Radiology (D.v.W.), Department of Clinical Sciences Lund, Lund University; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK.
Daniel LindqvistFrom the Clinical Memory Research Unit (K.N., A.-M.G., E.S., O.H.) and Clinical Research Centre (O.M.), Department of Clinical Sciences Malmö, Lund University; Memory Clinic (K.N., A.-M.G., E.S., O.H.), Skåne University Hospital, Malmö; Psychiatry (D.L.) and Diagnostic Radiology (D.v.W.), Department of Clinical Sciences Lund, Lund University; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK.
Danielle van WestenFrom the Clinical Memory Research Unit (K.N., A.-M.G., E.S., O.H.) and Clinical Research Centre (O.M.), Department of Clinical Sciences Malmö, Lund University; Memory Clinic (K.N., A.-M.G., E.S., O.H.), Skåne University Hospital, Malmö; Psychiatry (D.L.) and Diagnostic Radiology (D.v.W.), Department of Clinical Sciences Lund, Lund University; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK.
Kaj BlennowFrom the Clinical Memory Research Unit (K.N., A.-M.G., E.S., O.H.) and Clinical Research Centre (O.M.), Department of Clinical Sciences Malmö, Lund University; Memory Clinic (K.N., A.-M.G., E.S., O.H.), Skåne University Hospital, Malmö; Psychiatry (D.L.) and Diagnostic Radiology (D.v.W.), Department of Clinical Sciences Lund, Lund University; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK.
Henrik ZetterbergFrom the Clinical Memory Research Unit (K.N., A.-M.G., E.S., O.H.) and Clinical Research Centre (O.M.), Department of Clinical Sciences Malmö, Lund University; Memory Clinic (K.N., A.-M.G., E.S., O.H.), Skåne University Hospital, Malmö; Psychiatry (D.L.) and Diagnostic Radiology (D.v.W.), Department of Clinical Sciences Lund, Lund University; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK.
Olle MelanderFrom the Clinical Memory Research Unit (K.N., A.-M.G., E.S., O.H.) and Clinical Research Centre (O.M.), Department of Clinical Sciences Malmö, Lund University; Memory Clinic (K.N., A.-M.G., E.S., O.H.), Skåne University Hospital, Malmö; Psychiatry (D.L.) and Diagnostic Radiology (D.v.W.), Department of Clinical Sciences Lund, Lund University; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK.
Oskar HanssonFrom the Clinical Memory Research Unit (K.N., A.-M.G., E.S., O.H.) and Clinical Research Centre (O.M.), Department of Clinical Sciences Malmö, Lund University; Memory Clinic (K.N., A.-M.G., E.S., O.H.), Skåne University Hospital, Malmö; Psychiatry (D.L.) and Diagnostic Radiology (D.v.W.), Department of Clinical Sciences Lund, Lund University; Department of Psychiatry and Neurochemistry (K.B., H.Z.), Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; and Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK. katarina.nagga@med.lu.se oskar.hansson@med.lu.se.
University College London · GBLund University · SENational Hospital for Neurology and Neurosurgery · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the effect of midlife lipid levels on Alzheimer brain pathology 20 years later in cognitively normal elderly individuals.

methodsThis is a longitudinal cohort study of 318 cognitively normal individuals with data on fasting lipid levels at midlife (mean age 54 years). Presence of β-amyloid (Aβ) and tau pathologies 20 years later (mean age 73 years) were detected by quantifying Alzheimer disease (AD) biomarkers in CSF. In a subset (n = 134), Aβ (

resultsCSF Aβ

conclusionsIncreased levels of triglycerides at midlife predict brain Aβ and tau pathology 20 years later in cognitively healthy individuals. Certain lipoprotein subfractions may also be risk factors for Aβ pathology. These findings further support an involvement of lipids in the very early stages of AD development.

Indexed as

AgedAlzheimer DiseaseAmyloid beta-PeptidesAniline CompoundsApolipoprotein E4BenzothiazolesBiomarkersBrainFemaleFollow-Up StudiesHumansLongitudinal StudiesMalePositron-Emission TomographyRadiopharmaceuticalsRisk FactorsAmyloid beta-PeptidesAniline CompoundsApolipoprotein E4BenzothiazolesBiomarkersflutemetamolMAPT protein, humanRadiopharmaceuticalstau ProteinsTriglycerides

Identifiers

PMID29196581
PMCPMC5754649
OpenAlexW2775635068

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.