ArticleThe Journal of biological chemistry2017
Stem cells take the stairs.
Caroline Vissers, Guo-Li Ming, Hongjun Song
Abstract read
In one paragraphArticle in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
3 authors.
Caroline VissersFrom The Graduate Program of Biochemistry, Cellular, and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 and.
Guo-Li MingFrom The Graduate Program of Biochemistry, Cellular, and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 and.
Hongjun SongFrom The Graduate Program of Biochemistry, Cellular, and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 and shongjun@pennmedicine.upenn.edu.
Funding
BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1MRole of CACNA1C - a shared risk gene in neuropsychiatric disordersU19MH106434 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GAGE, FRED H · 2016 to 2020
$13.8MModeling Zika virus pathogenesis and potential intervention during neural development using a human brain organoid systemU19AI131130 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI WEN, ZHEXING · 2017 to 2021
$7.7MFunctional roles of genetic risk factors for brain disorders in neurogenesis and neurodevelopmentR35NS097370 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MING, GUO-LI · 2017 to 2024
$6.7MTranslational models of neurodevelopmental epigenetics and disease using human iPSCsP01NS097206 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI HE, CHUAN · 2016 to 2020
$4.3MFunctional characterization of Alzheimer's disease associated genetic variantsR01AG057497 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GAN, LI, SHEN, YIN · 2017 to 2021
$4.2MLocal circuitry mechanisms regulating adult hippocampal neurogenesisR37NS047344 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SONG, HONGJUN · 2013 to 2019
$2.9MCircuitry mechanisms underlying normal and aberrant adult hippocampal neurogenesisR01MH105128 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI MING, GUO-LI · 2014 to 2018
$2.0MNIAID NIH HHS U19 AI131130NIA NIH HHS R01 AG057497NIGMS NIH HHS T32 GM007445NIMH NIH HHS R01 MH105128NIMH NIH HHS U19 MH106434NINDS NIH HHS P01 NS097206NINDS NIH HHS R35 NS097370NINDS NIH HHS R37 NS047344
6 · The paper itselfAbstract
Human embryonic stem cells progress through multiple stages in their path to neural differentiation, but the steps taken along the way are difficult to distinguish, limiting our understanding of this important process. Jing and colleagues (2) now report comprehensive analyses of transcriptome dynamics during this process that reveal five discrete stages, defined in part by highly connected transcription factor networks that link progressive stages. Surprisingly, the third stage, which appears to be critical for neural fate commitment, depends almost entirely on intracellular signaling.
Indexed as
Cell DifferentiationEmbryonic Stem CellsHumansSequence Analysis, RNASignal TransductionTranscription FactorsTranscriptomeTranscription Factors
Identifiers
PMID29196569
PMCPMC5712602
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