Evidence map›Paper›PMID 29196461›Full record

ArticleThe Journal of cell biology2018

miRNA suppression of a Notch repressor directs non-neuronal fate in

Joshua Kavaler, Hong Duan, Rajaguru Aradhya, Luis F de Navas, Brian Joseph, Boris Shklyar, Eric C Lai

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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  5. TheDevelopment (Cambridge, England) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Joshua KavalerDepartment of Biology, Colby College, Waterville, ME.ORCID 0000-0002-4603-5781
Hong DuanDepartment of Developmental Biology, Sloan-Kettering Institute, New York, NY.
Rajaguru AradhyaDepartment of Developmental Biology, Sloan-Kettering Institute, New York, NY.
Luis F de NavasDepartment of Developmental Biology, Sloan-Kettering Institute, New York, NY.
Brian JosephDepartment of Developmental Biology, Sloan-Kettering Institute, New York, NY.
Boris ShklyarDepartment of Developmental Biology, Sloan-Kettering Institute, New York, NY.
Eric C LaiDepartment of Developmental Biology, Sloan-Kettering Institute, New York, NY laie@mskcc.org.ORCID 0000-0002-8432-5851
Kettering University · USColby College · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Selective regulatory and biogenesis mechanisms for microRNAsR01GM083300 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI Eric C Lai · 2007 to 2026
$9.8M
Mechanism and regulation of Hu family RNA binding proteins during neural alternative polyadenylationR01NS083833 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI LAI, ERIC C · 2014 to 2023
$5.4M
BEN factors are conserved CSL co-repressors in Notch-mediated neural developmentR01NS074037 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI LAI, ERIC C · 2011 to 2015
$2.1M
NCI NIH HHS P30 CA008748NIGMS NIH HHS R01 GM083300NINDS NIH HHS R01 NS074037NINDS NIH HHS R01 NS083833
6 · The paper itself

Abstract

Although there is abundant evidence that individual microRNA (miRNA) loci repress large cohorts of targets, large-scale knockout studies suggest that most miRNAs are phenotypically dispensable. Here, we identify a rare case of developmental cell specification that is highly dependent on miRNA control of an individual target. We observe that binary cell fate choice in the

Indexed as

AnimalsDrosophila melanogasterDrosophila ProteinsMicroRNAsReceptors, NotchDrosophila ProteinsMicroRNAsN protein, DrosophilaReceptors, Notch

Identifiers

PMID29196461
PMCPMC5800810
OpenAlexW2773131035

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.