ArticleThe Journal of general physiology2018
Integrative model of coronary flow in anatomically based vasculature under myogenic, shear, and metabolic regulation.
Article in The Journal of general physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- A microstructurally motivated framework to study autoregulation in the coronary circulation.The Journal of physiology · 2026Article
- A Microstructurally-Motivated Framework to Study Autoregulation in the Coronary Circulation.bioRxiv : the preprint server for biology · 2025Article
- Computer model coupling hemodynamics and oxygen transport in the coronary capillary network: Pulsatile vs. non-pulsatile analysis.Computer methods and programs in biomedicine · 2025Article
- Mechanisms of coronary sinus reducer for treatment of myocardial ischemia: in silico study.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Unraveling the Gordian knot of coronary pressure-flow autoregulation.Journal of molecular and cellular cardiology · 2024Review
- Simulation of coronary capillary transit time based on full vascular model of the heart.Computer methods and programs in biomedicine · 2024Article
- Mechanism of exercise intolerance in heart diseases predicted by a computer model of myocardial demand-supply feedback system.Computer methods and programs in biomedicine · 2022Article
- Optimization of cardiac resynchronization therapy based on a cardiac electromechanics-perfusion computational model.Computers in biology and medicine · 2022Article
- Role of coronary flow regulation and cardiac-coronary coupling in mechanical dyssynchrony associated with right ventricular pacing.American journal of physiology. Heart and circulatory physiology · 2021Article
- Transmural Distribution of Coronary Perfusion and Myocardial Work Density Due to Alterations in Ventricular Loading, Geometry and Contractility.Frontiers in physiology · 2021Article
- Effects of myocardial function and systemic circulation on regional coronary perfusion.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Overview of mathematical modeling of myocardial blood flow regulation.American journal of physiology. Heart and circulatory physiology · 2020Review
- Effects of Mechanical Dyssynchrony on Coronary Flow: Insights From a Computational Model of Coupled Coronary Perfusion With Systemic Circulation.Frontiers in physiology · 2020Article
- Topologic and Hemodynamic Characteristics of the Human Coronary Arterial Circulation.Frontiers in physiology · 2019Article
- Role of Coronary Myogenic Response in Pressure-Flow Autoregulation in Swine: A Meta-Analysis With Coronary Flow Modeling.Frontiers in physiology · 2018Article
- Computational Assessment of Blood Flow Heterogeneity in Peritoneal Dialysis Patients' Cardiac Ventricles.Frontiers in physiology · 2018Article
- Morphometric Reconstruction of Coronary Vasculature Incorporating Uniformity of Flow Dispersion.Frontiers in physiology · 2018Article
- Review of cardiac-coronary interaction and insights from mathematical modeling.WIREs mechanisms of diseaseReview
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Coronary blood flow is regulated to match the oxygen demand of myocytes in the heart wall. Flow regulation is essential to meet the wide range of cardiac workload. The blood flows through a complex coronary vasculature of elastic vessels having nonlinear wall properties, under transmural heterogeneous myocardial extravascular loading. To date, there is no fully integrative flow analysis that incorporates global and local passive and flow control determinants. Here, we provide an integrative model of coronary flow regulation that considers the realistic asymmetric morphology of the coronary network, the dynamic myocardial loading on the vessels embedded in it, and the combined effects of local myogenic effect, local shear regulation, and conducted metabolic control driven by venous O
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