Evidence map›Paper›PMID 29196269›Full record

ArticleNeuroImage2018

Diffusion MRI and MR spectroscopy reveal microstructural and metabolic brain alterations in chronic mild stress exposed rats: A CMS recovery study.

Ahmad Raza Khan, Brian Hansen, Ove Wiborg, Christopher D Kroenke, Sune Nørhøj Jespersen

Open access · goldAbstract read
In one paragraph

Article in NeuroImage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
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  4. Review
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  8. Characterization of theJournal of clinical medicine · 2021
    Article
  9. The Changes inJournal of molecular neuroscience : MN · 2021
    Article
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  14. Review
  15. Article
  16. An Introduction to Kurtosis Fractional Anisotropy.AJNR. American journal of neuroradiology · 2019
    Review
  17. REM sleep's unique associations with corticosterone regulation, apoptotic pathways, and behavior in chronic stress in mice.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Ahmad Raza KhanCenter of Functionally Integrative Neuroscience, Aarhus University Hospital, Aarhus, Denmark.
Brian HansenCenter of Functionally Integrative Neuroscience, Aarhus University Hospital, Aarhus, Denmark.
Ove WiborgCenter of Functionally Integrative Neuroscience, Aarhus University Hospital, Aarhus, Denmark.
Christopher D KroenkeAdvanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States.
Sune Nørhøj JespersenCenter of Functionally Integrative Neuroscience, Aarhus University Hospital, Aarhus, Denmark; Department of Physics and Astronomy, Aarhus University, Aarhus, Denmark. Electronic address: sune@cfin.au.dk.
Aarhus University Hospital · DKAarhus University · DKAdvanced Imaging Research (United States) · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Development of MR Microscopy at the Cellular LevelR01EB012874 · NIBIB · UNIVERSITY OF FLORIDA · PI BLACKBAND, STEPHEN J. · 2010 to 2013
$2.1M
NIBIB NIH HHS R01 EB012874NIH HHS P51 OD011092
6 · The paper itself

Abstract

Chronic mild stress (CMS) induced depression elicits several debilitating symptoms and causes a significant economic burden on society. High variability in the symptomatology of depression poses substantial impediment to accurate diagnosis and therapy outcome. CMS exposure induces significant metabolic and microstructural alterations in the hippocampus (HP), prefrontal cortex (PFC), caudate-putamen (CP) and amygdala (AM), however, recovery from these maladaptive changes are limited and this may provide negative effects on the therapeutic treatment and management of depression. The present study utilized anhedonic rats from the unpredictable CMS model of depression to study metabolic recovery in the ventral hippocampus (vHP) and microstructural recovery in the HP, AM, CP, and PFC. The study employed

Indexed as

AmygdalaDepressionHippocampusStress, PsychologicalAnhedoniaAnimalsDiffusion Magnetic Resonance ImagingDisease Models, AnimalHumansMaleProton Magnetic Resonance SpectroscopyRatsRats, Long-Evans(1)H MRSAmygdalaChronic mild stressDiffusion MRIHippocampusKurtosis

Identifiers

PMID29196269
PMCPMC5845761
OpenAlexW2768165855

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.