ArticleCell metabolism2017
GDF15-From Biomarker to Allostatic Hormone.
Article in Cell metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Exploration of treatment strategies and susceptibility gene of postoperative nausea and vomiting in breast cancer patients: a randomised controlled trial.Breast cancer (Tokyo, Japan) · 2024Trial
- GDF15 Is Elevated in Conditions of Glucocorticoid Deficiency and Is Modulated by Glucocorticoid Replacement.The Journal of clinical endocrinology and metabolism · 2020Trial
- The causes of cachexia: key signals and the brain.Nature reviews. Endocrinology · 2026Review
- GDF15: A Novel Insight Into Its Biology and Therapeutic Potential in Obesity.Journal of diabetes research · 2026Review
- GDF15 links adipose tissue lipolysis with anxiety.Nature metabolism · 2025Article
- Proximate and ultimate causes of pregnancy sickness.Evolution, medicine, and public health · 2025Review
- GDF15 antagonism limits severe heart failure and prevents cardiac cachexia.Cardiovascular research · 2024Article
- Circulating total and H-specific GDF15 levels are elevated in subjects with MASLD but not in hyperlipidemic but otherwise metabolically healthy subjects with obesity.Cardiovascular diabetology · 2024Observational
- Article
- The search for systemic biomarkers for monitoring degenerative lumbar spinal disorders.Osteoarthritis and cartilage open · 2022Article
- Growth differentiation factor 15 (GDF15) is associated with non-alcoholic fatty liver disease (NAFLD) in youth with overweight or obesity.Nutrition & diabetes · 2022Article
- Coping With Stress: The Mitokine GDF-15 as a Biomarker of COVID-19 Severity.Frontiers in immunology · 2022Review
- Cutting Edge: CD36 Mediates Phagocyte Tropism and Avirulence ofJournal of immunology (Baltimore, Md. : 1950) · 2021Article
- Serum growth differentiation factor-15 analysis as a malnutrition marker in hemodialysis patientsTurkish journal of medical sciences · 2021Article
- Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- GDF15/GFRAL Pathway as a Metabolic Signature for Cachexia in Patients with Cancer.Journal of Cancer · 2021Review
- GDF15: A Hormone Conveying Somatic Distress to the Brain.Endocrine reviews · 2020Review
- CXCL5-mediated recruitment of neutrophils into the peritoneal cavity ofProceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
- Comment on
Authors and funding
1 author.
Funding
Abstract
With the identification of its receptor in a highly specific region of the brain, interesting issues come to light regarding the normal physiological functions of GDF15, a secreted protein long identified as a biomarker of diverse disease states.
Indexed as
Identifiers
29195860What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.